Antidiabetics - drugs, possessing the ability to reduce the level of sugar in blood. Applied for the treatment of diabetes. To protivodiabeticakih funds are insulin (see) and the group of sulfa drugs (see Butamid, Ziklomed, Hlorpropamid). For the treatment of diabetes currently also used funds from the group biguanidov (debit, phenformin).
Insulin when introduced into the body lowers the maintenance of sugar in the blood, reduce its excretion, increase glycogen in the muscles, normalization of lipid and protein metabolism. The activity of insulin determined by biological and expressed in units of (ED). Insulin is effective only when parenteral introduction.
Unlike insulin preparations, sulfanilamidnykh protivodiabeticakih funds effective when administered. Therapeutic effects of sulfa drugs most likely caused by stimulation of beta-cells of the islets of Langerhans of the pancreas and increased insulin secretion. Sulfanilamidnykh protivodiabeticakih funds are used in the treatment of patients over the age of 40 years, not applying large doses of insulin, with moderate form of diabetes, when diet therapy does not correct hyperglycemia. Contraindications to the use sulfanilamidnykh protivodiabeticakih funds: mild form of diabetes mellitus, ketosis, and diabetic coma or prekomatosny state in history; high hyperglycemia (>250 mg%), continuing in diet therapy; in the case of applications for compensation of diabetes and metabolism disorders of insulin 40 U and more); diseases of the bone marrow, the liver and kidneys.
To protivodiabeticakih funds is also lipokain (see), which is used in the treatment of diabetes with a tendency to ketosis.
It should be borne in mind that in case of exceeding the dose of insulin and untimely meal may experience hypoglycemia, expressed the feeling of hunger, weakness, tachycardia, increased sweating, trembling of the hands and feet, institution or lethargy. In the future can lead to loss of consciousness and seizures. With symptoms of hypoglycemia patient should eat 100 grams of white bread or 50 and biscuits. If the state of hypoglycemia persists, you should eat 2-3 teaspoons of sugar, or some sweets; if necessary, sugar , take repeated every 3 to 5 minutes until you resolve hypoglycemic events. In heavy gipoglikemii (with loss of consciousness) should be administered intravenously 50 ml of 40% glucose solution; if the consciousness of the patient is not restored, repeat injection. If it is impossible to enter glucose intravenous resort to subcutaneous drip infusion of 500 ml 5-6% solution.