Protivogistaminne means

Protivogistaminne means - group substances that can prevent or suppress the action of histamine. In addition to derivatives fenotiazina - promethazine (see), atesin (see),protivogistaminne means include substances of different chemical structure - diphenhydramine (see), diazolin (see), suprastin.
Protivogistaminne means warn caused gistaminom spasm of the musculature of the bronchi and intestines, reduces the hypotensive action of histamine, reduces the permeability of capillaries and prevent the development occurs under the influence of histamine edema. Protivogistaminne means not prevent the increased secretion of gastric juice, caused gistaminom.
In addition antihistaminics activity, a number protivogistaminne means (promethazine, atesin and diphenhydramine) causes sedative and hypnotic effects, has antiemetic activity.
Protivogistaminne means used in allergic conditions (hives, hay fever, vasomotor rhinitis, allergic conjunctivitis, swelling Kwinke, occupational dermatitis, eczema, purpura nervosa), as well as drug allergies, radiation sickness , and to reduce the allergic reactions of the transfusion of blood and blood fluids. Protivogistaminne means has sedative properties, effective for sea and air sickness, Meniere's syndrome. Antihistamines funds that have a depressant effect on the Central nervous system cannot be assigned during transport drivers and other persons profession which requires quick mental and motor reaction.

Protivogistaminne means (antihistamines) - a group of substances that can inhibit the action of histamine at the individual organs and the whole organism. Antihistamines warn caused gistaminom spasm of the musculature of the bronchi and intestines, reduces its impact on the circulation of the blood, prevents the increased capillary permeability due to the introduction of histamine, make it easier for anaphylactic reactions. Antihistamines do not prevent hypersecretion of gastric juice, caused by histamine; not have a significant impact on the formation and release of histamine and do not violate the reaction antigen-antibody. Most likely that their antihistaminics activity due to the competitive relationship with histamine and blocking gistaminolitiki receptor cells of smooth muscles and glands.
Pharmacological effect of antihistamines is not limited to anti-histamine properties.
They have also other modes of pharmacological activity [holino - and adrainoliticescoy activity, spasmolytic (myotropic action and anesthetic properties]that in some cases extends the possibility of their therapeutic applications. Many antihistamines have a dampening effect on the Central nervous system, called sedative and hypnotic effects, enhance the effect of drugs, analgesic and anaesthetics, prevent nausea and vomiting in sea and air sickness, calm vomiting pregnant, have anticonvulsant activity. These properties are the most pronounced in derivatives fenotiazina (see Promethazine, Etsin), to a lesser degree - Dimedrol (see) and significantly weaker - suprastin. Some antihistamines, such as diazolin (see), lack of depressive effect on the Central nervous system.
Antihistamine used mainly in allergic conditions: hives, hay fever, allergic and vasomotor rhinitis, allergic conjunctivitis, swelling Kwinke, drug allergies, professional dermatitis, eczema, purpura nervosa, Meniere's disease, in the early stages of asthma, to reduce the reactions of the transfusion of blood and blood fluids. Treatment antihistamines is symptomatic and held prior to the onset of spontaneous or artificial desensitization. Some antihistamines (Dimedrol, promethazine) can be used for the prevention of sea and air sickness as sedatives, and in the treatment of parkinsonism, horei, vomiting pregnant, radiation sickness, to resolve vestibular disorders.
Antihistamines are well-absorbed as when parenteral introduction, and by ingestion. Duration of the effect of 3-6 hours. (promethazine, diphenhydramine, suprastin) to 1 - 2 days.
Antihistamines are used inside usually in doses 0,025-0,05 g and injection (under the skin, intramuscular and intravenous) - 0,025 g At skin manifestations of Allergy antihistamine can also be used topically in the form of lotions. Antihistamines are low-toxic and generally well tolerated, but in individuals they may cause dizziness. Known cases of skin sensitization to the relevant antihistamines funds. With long-term use may develop leukopenia. Due to the presence of a number of antihistamines local irritating effect when injected under the skin, sometimes there infiltrates. In the appointment of antihistamines is necessary to take into account side properties inherent to the different representatives of this group (a dampening effect on the Central nervous system, holinoliticaskoy activity and others). When liver disease and kidney antihistamines should be used with caution.