Antifungal agents

Antifungal agents - drugs used to treat fungal infections. To antifungal tools include substances of different chemical structure, providing local and common action. Topically for the treatment of fungal infections active free halides (iodine), phenols and their geluidisolatie, unsaturated fatty acids with long hydrocarbon chains (undecylenoyl acid), antibiotics (nystatin, levorin), derived nitrofurana (nitrofural), salts of heavy metals, organic compounds of mercury, compounds of sulfur and other common activities use griseofulvin and nystatin.
To treat fungal infections of smooth skin and mucous membranes (athlete's foot, trichophytosis, microsporia, candidiasis) use of highly active anti-fungal drugs. These drugs include: amicaal (see), aminophosphine (see), dekamina (see), dichas, levorin (see), Licata (see), nystatin (see), nitrofungin, nitrofuran (see), salicylanilide, undecen (see), linkungan (see). For a deeper penetration into the skin to the place of localization of pathogenic fungi number listed preparations prepare on special ointment bases, reinforcing the penetrating ability of antifungal agents.
Local treatment of fungal infections of the hair and nails is difficult because antifungal agents local actions do not penetrate into the hair follicles and the nail plate. Therefore, the treatment of such mycosis pre make the hair (hair removal, together with the bulb) by using the patch epilinovogo (see) and the removal of the nail plate (see Oniholizis), then apply antifungal agents.
An important achievement is the opening griseofulvin (see), which proved to be effective for the treatment of fungal infections smooth skin, scalp and nails by ingestion.
To treat candidiasis of internal organs using nystatin.

Antifungal medicines, medicines used to treat fungal infections, can be divided into applicable local, tools and common actions. For the treatment of fungal infections of the skin smooth successfully used fungistatic and fungicidal agent of the different chemical nature. High activity have free halides, especially iodine, phenols and their geluidisolatie, salicylic acid and its geluidisolatie, annelid salicylic acid and its geluidisolatie, fatty acids with long carbon chains, especially unsaturated (for example, undecylenoyl acid), 5,7-geluidisolatie 8-okshihinolina, salts of heavy metals (zinc, copper, mercury), organic mercury compounds, sulphur compounds (elementary sulfur, sulphide, mercaptans and other
For successful actions and fungistatic and fungicidal agents at treatment of dermatomycoses need so they penetrate the skin, to the place of localization of pathogenic fungi. The penetrating ability of antifungal agents may be enhanced by the use of appropriate mazevyh bases (surface active substances) and special contributing additives, such as monoaminov of ethylene glycol (ethylcellosolve), soluble in both water and organic solvents and are good solvents of various substances. The simultaneous use of antifungal agents of different chemical nature leads to increase in their actions. For practical application created a number of finished products on a rational ointment bases, containing highly active antifungal substances and their combinations. These drugs include undecen (see), linkungan (see), ustunden (undecylenoyl acid - 5%, undecylenate zinc - 10%, annelid salicylic acid - 10%, talc - 75%), aminophosphine [bis(ethoxythiophene)-disulfide-bis-(N-ethyl-N-octadecylamine; used in the form of 3% ointment or 3% gloves], nitrofungin (2-chloro-4-NITROPHENOL - 1 year, triethylene glycol - 10 g, ethyl alcohol 50 degrees up to 100 ml), afangel (2-methyl-5, 7-dichloro-8-oksihinolina - 5%, ointment base - 95%). As local antifungal agents used amicaal (see), dichas (2-chloraniline-5-floralicious acid) in the form of 1% and 3% ointment and dekamina (see) in the form of 0.5% and 1% emulsionnyh ointments.
Local treatment of fungal infections of the hair is difficult because antifungal agents local actions do not penetrate into the hair follicles to the place of localization of fungi in the hair. For successful treatment of mycosis need to resort to hair removal - hair-removal together with onions. For epilation apply the scalp irradiation with high doses of x-rays or 4% epilinovy patch (see). The imposition of the patch epilinovogo dose of 12 grams (adult) on the skin of any part of the body for a period of 20 days leading to the election of hair on the scalp; hair grows again after 1.5-2 months. The period of baldness is quite sufficient for radical anti-fungal therapy. For treating oily scalp applied sulsenovoe soap and toothpaste (see Culsen).
For the treatment of fungal infections of the mucous membrane (candidiasis) apply an antibiotic nystatin (see) and the dekamina. To treat candidiasis mucous membranes of the oral cavity dekamina used in the form of caramel for sucking (dekumanova caramel).
A great achievement of the last time is the opening of funds to treat fungal infections. For the General treatment of ringworm griseofulvin used (see)having fungistatic action. It comes in two forms: griseofulvin and griseofulvin-Forte. The latter is a fine form grizeofulvina, with the best absorption in the intestine and, in this regard, a higher activity. To treat candidiasis internal organs used nystatin and antibiotic amphotericin Century, But the first is poorly absorbed from the gastrointestinal tract, the latest highly toxic.