Antimalarials

Antimalarials drugs used to treat and prevent malaria.
To antimalarial tools include the following drugs: quinine (see), Akrikhin (see), bigumal (see), hingamin (see), Galkin, hloridin (see), hinotsid (see), plasmacid (cm).
Antimalarials share for the electoral act for the various forms of Plasmodium, as well as by predominant effect on the different types malaria Plasmodium. Quinine, Akrikhin, hingamin, Galkin, hloridin selectively act on the erythrocytic forms of Plasmodium malaria (gametocytaemia drugs). These funds cropped acute febrile episodes of malaria, however, the radical cure they don't give as little effect on paralimnocythere forms of Plasmodium, which cause the appearance of relapses of malaria. These drugs are not significantly affect the sexual form of the malaria parasite. Therefore, they do not prevent the further spread of the disease through mosquitoes and may not be used for social prevention of malaria. At the same time for individual prevention gametocytaemia funds use, because they warn clinical manifestations of malaria by inhibiting the reproduction of parasites in the blood.
The special situation of the nature of antimalarial action is bigumal. This drug is effective against the pathogen tropical malaria. It affects both erythrocyte and sexual forms malaria Plasmodium.
To prevent a recurrence of malaria is mostly hinotsid, which is particularly effective against preerythrocytic forms of Plasmodium. Hinotsid appointed after the course of treatment gepatocitami means. This provides a radical cure of the patient.
For social prevention of malaria using drugs that affect the sexual forms of Plasmodium,plasmacid, bigumal. These antimalarials prevent infestation mosquitoes against malaria patients and prevent further spread of the disease. The main means of public chemoprophylaxis is plasmoid. It is prescribed together with gepatocitami anti-malarial drugs to achieve simultaneously clinical and prophylactic effect.
In the application of anti-malaria drugs is observed the development of drug resistance malaria Plasmodium. Particularly easy it develops to bigumalyu and hloridine.
Antimalarials are not only used for treating malaria, but also some other diseases caused by protozoaand worms. So, Akrikhin used to treat amebiasis, giardiasis, leishmaniasis, of cestodoses; hloridin used for toxoplasmosis.

Antimalarials drugs used for chemotherapy and chemoprophylaxis of malaria. The activity of anti-malaria drugs is manifested differently in relation to the different stages of development of the malaria parasite in the body. Sometimes the effect is most pronounced in respect of any one stage or more. Depending on the nature of effects antimalarials are divided into several groups. Schizontocidal drugs - drugs with activity against asexual development of the malaria parasite (schizonts); blood schizontocidal drugs - means that suppress the development of schizonts in erythrocytes; PERVICHNAYA schizontocidal drugs active against primary and vtorichnoie schizontocidal drugs - in relation to a secondary Exo-erythrocytic forms. In accordance with this blood schizontocidal drugs used for the prevention and cupping malaria. Reducing the number of Plasmodium in the blood, blood schizontocidal drugs cause reduction and sexual forms. In tropical malaria they radically cure the disease. PERVICHNAYA schizontocidal drugs used for causal prevention. They prevent the development of red blood cell schizogony. Only in exceptional cases may occur late bouts of malaria. Vtorichnoie schizontocidal drugs shown for the radical treatment of malaria patients undergoing three - and four-day malaria.
Drugs that act on gamonty - gametocyte - causes the disappearance of sex forms malaria parasite from the blood or break the cycle of his sexual development in the mosquito. The latter can disrupt the reproductive cycle of the parasite in the body of the mosquito at the stage of exflagellation. Drugs to stop the growth cycle at the stage of ookinete, are called torontoci.com.
Antimalarial activity was observed in many classes of chemical compounds. The most widely used derivatives of 4-aminoquinoline - hingamin (see), Galkin These and other blood schizontocidal drugs have the highest efficiency among other anti-malaria drugs. A similar effect has derived 9 aminoacridine - Akrikhin (see) and quinine (see). Derivative 8-aminoquinoline - plasmoid (see), hinotsid (see) - have a wide range of actions. They are active against both sexual and tissue forms of malaria Plasmodium. As blood schizontocidal drugs they are relatively inactive. Hinotsid more plasmoid in relation to a secondary tissue forms.
Derivatives fenilpirido - bigumal (see) and others - have the effect of blood and pericratonic of schizontocidal drugs and sporotsidnoe activity. Derivatives of 2,4-diamino-5-phenyl-pyrimidine - hloridin (see) and the other is active against blood schizonts (effect on tissue schizonts are less) and have sporotsidnoe action.
For cupping malaria apply the blood schizontocidal drugs: hingamin, Galkin, Akrikhin, quinine. For the radical treatment of malaria after treatment blood schizontocidal drugs used hinotsid.
Malaria prevention is carried out according to the testimony of various anti-malarial drugs. Spring treatment of anti - blood schizontocidal drugs. For public chemoprophylaxis, i.e. to break the epidemiological chain man - mosquito appoint gametocyte in combination with blood schizontocidal drugs. For individual prevention appoint blood and PERVICHNAYA schizontocidal drugs. Precipitations chemoprophylaxis perform using hinotsida.
In the application of anti-malaria drugs is observed the development of drug resistance malaria Plasmodium. Particularly easy it develops to bigumalyu and hloridine. Described cases of occurrence of resistance to Akrikhin, quinine and hingamina.