Anti-inflammatory resolving treatment

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Around active foci of endometriosis always develop an inflammatory reaction in the form of infiltrative cicatricoadhesive changes. This is due to periodic hit in the surrounding tissue (empiriomonism) menstrualnopodobne detachable, enzymes and products of destruction of tissues grow their endometriosis, including components kininogen-kinin system and other biologically active substances. The severity of the inflammatory response in different localization of endometriosis is not the same. Most inflammatory changes are expressed in pozavchera endometriosis, the defeat of the pararectal cellular and paravaginal fiber, endometriosis post-operative scars and subcutaneous tissue, ovarian and bowel.
Centers around ectocervical endometriosis, cervical inflammatory reaction is, but is detected, it is usually only a histological examination of the drug. In the wall of the body and neck of the uterus is determined by the hardening of tissue, which is a consequence of the inflammatory reaction. Especially expressed it in the isthmus of the uterus. This is largely due to the difficulty of cervical dilatation diagnostic scraping her and abortion.
Infiltrative and scar-fibrous tissue changes in the field of localization of foci of endometriosis is not only due to its cyclical turning, but, apparently, contribute penetrating the growth of endometriosis in adjacent thereto tissue. This may indicate the results of the audit of the abdominal cavity and pelvis during operations for endometriosis and the results of the histological examination biopsia-cell material. First, the rectum or urethra grow together with active foci of endometriosis (pozavcherashny its localization or ovaries), these bodies can separate the acute way, often without opening their lumens. If we operate on the patient in the later stages of the disease, it is rarely possible to do without opening the lumen of the body, and in resected area of the walls of the bowel, bladder or ureter are glands and stroma of the endometrium. Thus the wall of the bowel and bladder in place of incarceration of endometriosis is much thicker.
Infiltrative and cicatricial changes in the isthmus of the uterus, spreading in the back wall of the bladder, causing dysuric phenomena, and during the operation significantly complicate the separation of the bladder from the isthmus of the uterus; this can be done only by acute.
Another feature of inflammatory processes, due to cyclical transformation of the foci of endometriosis. We are talking about the development of dysbacteriosis and candidiasis cancer, Candida in the vagina, urinary tract system and other organs. Dysbacteriosis and intestinal candidiasis clinically manifested chronic relapsing colitis, intestinal discomfort (meteorism and constipation alternating with purgative effect)may develop severe ulcer hemorrhagic colitis. Candidiasis of the urinary system is manifested chronic relapsing pyelocystitis and urethritis. Vaginal candidiasis gives a picture of resistant fungal vaginitis, can join chlamydia and micoplasma hominis. The reason for the development of dysbacteriosis and candidiasis is intensive (often unnecessary, since inflammation is secondary and is aseptic character) antibacterial therapy, carried out repeatedly about each of exacerbation of the inflammatory process. This also contributes to and hormonal therapy for endometriosis.
Available with endometriosis dysfunction of the immune system, strengthen candidiasis and dysbacteriosis, as well as the reduction of non-specific resistance of the organism due to irregularities in the antioxidant system support persistent nature of inflammation, caused by endometriosis, and the tendency of his quick to generalize when layering anaerobic etiology and pyogenic.
Based on the above, we believe the inclusion of antibacterial preparations in complex treatment of patients with endometriosis unreasonable, even if you receive hyperthermia during periods of exacerbation. Body temperature drops within 3-4 days without antibacterial therapy. The situation changed in the cases of secondary bacterial factor when hyperthermia is delayed, appear and grow phenomena of intoxication.
Persistent relapsing inflammatory process caused by endometriosis, promotes the growth of allergization of the organism. This feature should also be considered in the treatment.
Taking into account considerations expressed in complex treatment should be included hormonal preparations aimed at the suppression of activity of endometriosis, anti-inflammatory and resolving factors. As for hormonal drugs, the dose of their many patients with small foci of endometriosis and expressed cicatricial inflammatory inflammatory reaction around them can be reduced. The reason for this is some reduction estrogenic stimulation under the influence of long-flowing and often relapsing inflammatory process.