Anti-inflammatory drugs

Anti - inflammatory drugs-drug-substances that reduce the inflammatory response. There are anti-inflammatory drugs etiotropic and pathogenetic actions. First - antibiotics (see), sulfonamides (see) and other chemotherapeutic drug - called anti-inflammatory effect for inflammation infectious nature, affecting microorganisms. Second suppress the inflammatory response, acting on its physiological mechanisms. To pathogenetically applicable anti-inflammatory remedies include glucocorticoids - cortisone (see), hydrocortisone (see) prednisolone (see), dexamethasone (see), sinalar and others In the eye and skin practice to use local, and in the treatment of rheumatism, rheumatoid arthritis and other collagenoses - resorptive anti-inflammatory action of these drugs. In connection with the fact that adrenocorticotropic hormone (see) of the anterior lobe of the pituitary gland triggers the release of glucocorticoids of the adrenal cortex, it is also referred to as anti-inflammatory agents. In the treatment of rheumatism, neuritis, myositis, of phlebitis widely used as a means of anti-derivative of salicylic acid, acetylsalicylic acid (see) and others; pirazolona - amidopyrine (see), butadiene (see), etc. as anti-inflammatory drugs in rheumatoid arthritis, systemic lupus red and other collagenoses in recent years used antimalarial drug hingamin (see). To the anti-inflammatory means referred to as ionized calcium supplements (see), as of Nona calcium condense capillary walls. The local application of anti-inflammatory effect is caused sossoudossoujiwath funds - adrenaline (see), ephedrine (see) and others for Their use in the treatment of inflammatory diseases of the nose and paranasal sinuses, and with conjunctivitis. Anti-inflammatory effect is the effect on inflamed tissue binding means (see) and enveloping means (see). These substances protect sensitive nerve endings from irritation and thereby eliminate reflexes that support the inflammatory process.

Anti-inflammatory drugs (Antiphlogistica) - medicinal substances, limit the intensity of the inflammatory reaction. There are anti-inflammatory drugs etiotropic and pathogenetic actions. To etiotropona current P.F. include antimicrobial agents (antibiotics, sulfa drugs, other chemotherapeutic agents), which are anti-inflammatory effect in inflammatory processes of the infectious nature; P.F. with pathogenic action of known substances which inhibit the inflammatory response due to the impact on the physiological mechanisms of its formation.
To pathogenetically existing tools include anti-inflammatory hormones napochechnikov crust with a predominant influence on carbohydrate and protein metabolism, i.e. the so-called glukokortikoida (see Cortisone, Prednisone). Glukokortikoida suppress exudative and proliferative components of the inflammatory response and strengthen its necrotic component. Anti-inflammatory effect of glucocorticoids explained by the fact that they reduce the permeability of blood vessels in the focus of inflammation and weaken the reaction of the connective tissue exposure cause inflammation agents. These effects of glucocorticoids, apparently, are the result of induced changes in tissue metabolism. Glukokortikoida cause anti-inflammatory effect as if resorptive and local action. Their anti-resorptive action are most widely used in the treatment of rheumatism, rheumatoid arthritis and other collagenoses. Local anti-inflammatory action of glucocorticoids use in ophthalmology and dermatology practice, and sometimes in the treatment of rheumatoid arthritis (injections of hydrocortisone in the joint cavity). As glukokortikoida weaken the immune response, which may contribute to the spread of infection, in their application in the conditions of infectious inflammation of nature, you enter into the body antibiotics (see) a wide spectrum of action. Glucocorticoid drugs for external use, manufactured in the form of ointments, as a rule, contain tetracycline antibiotics. Anti-inflammatory action has also adrenocorticotropic hormone (see) anterior pituitary, as it stimulates the release of glucocorticoids of the adrenal cortex.
Widely used anti-inflammatory drugs pathogenic action are derivatives of salicylic acid (see) and pyrazolone (see Antipyrine, amidopyrine, Analgin, Phenylbutazone), which is also used as an analgesic and fever-reducing medications. Anti-inflammatory action of sodium salicylate, acetylsalicylic acid (see), butadiona and amidopirina are most often used in the treatment of rheumatism, neuritis, myositis, phlebitis. The mechanism of anti-inflammatory action of these substances is not clear. It was suggested that as a result of their action on the Central nervous system increases the release of ACTH from the anterior pituitary, which in turn leads to increased secretion of glucocorticoids by the adrenal cortex. It was also noted that these substances inhibit the inactivation of glucocorticoids in the liver, and therefore increases the concentration in blood. However, the nature of the actions on metabolism salicylates and derivatives pirazolona significantly different from glukokortikoida, and therefore questioned the mediation actions of salicylates and derivatives pirazolona through the system pituitary - adrenal cortex. Anti-inflammatory effects of salicylates and derivatives pirazolona explain their inhibitory effects on the activity of hyaluronidase (see), resulting in reduced permeability tissue membranes. However, anti-inflammatory action of these substances is manifested in such concentrations in their blood, which do not significantly influence the activity of hyaluronidase.
Recently great importance in the formation of inflammatory reactions give bradykinin - polypeptide, which is formed from the serum globulins in the blood as a result of some of enzymatic reactions, activated causing inflammation agents. Experiments have shown, bradykinin expands blood vessels, increases the permeability of capillaries, which leads to the migration of leukocytes and, irritating nerves, causing pain. Thus, the formation of inflammatory reactions, possibly through the medium of bradykinin. There are data showing that the salicylates and derivatives pirazolona prevent the action of bradykinin, and impede their education.
Anti-inflammatory, analgesic, and antipyretic properties of cinchophen (see), which is used in the treatment of gout, as it also increases the excretion of uric acid.
As anti-inflammatory drugs in recent years has been the use of antimalarial drug hingamin (see), or chloroquine. It is used for the treatment of rheumatoid arthritis, systemic lupus erythematosus and other collagenoses. The mechanism of anti-inflammatory action hingamina unknown.
For anti-inflammatory remedies have long been referred to as ionized calcium supplements (see). Anti-inflammatory effect of calcium ions explain their sealing effect on tissue membranes, in particular on the walls of capillaries.
The local anti-inflammatory action in the effect of substances that are narrowing the blood vessels. Of these substances have the most value adrenaline (see), ephedrine (see) and other simpatomimeticalkie funds (see). They are used in the treatment of inflammatory diseases of the nose and paranasal his sinuses, and in the treatment of conjunctivitis. Anti-inflammatory effect is also achieved by the effect on inflamed tissue substances that protect sensitive nerve endings from irritating effects. This avoids the reflexes that support the inflammatory process. To the anti-inflammatory means of this type of actions are astringents (see), as well as coating means (see) and means of adsorption.