Pirogenal

Pirogenal (Pyrogenalum; list B) - lipopolysaccharide, formed in the process of vital activity of microorganisms Pseudomonas aeruginosa and other Pirogenal causes an increase in body temperature by 1-2 degrees and in the next 2-4 hours. Pyrogenic effect causes a number of changes in the body. Increases permeability of fabrics, hampered the development of scar tissue and other Applied with syphilitic lesions of the Central nervous system, to accelerate the resolution of scars and to stimulate recovery after diseases of Central and peripheral nervous system. Enter pirogenal intravenously and intramuscularly. Dose dependent on the nature of the disease and General condition of the patient. Average daily dose of 20-40 mg. The course of treatment 15 to 20 injections in 1-2 days. Side effects: headache, pain in joints and back pain, nausea, vomiting and herpetiformis rash. The use of pyrogenal is contraindicated in acute febrile illnesses. The release form: ampoules to 1 ml containing 10, 25, 50 and 100 mg of pyrogenal. Keep in dark place at a temperature of 2-4 degrees.

Pirogenal - lipopolysaccharide, obtained from Pseudomonas aeruginosa, Bact. typhi abdominalis and some other gram-negative bacteria and possessing distinct biological properties, including the ability to cause increased body temperature warm-blooded animals and man; in the chemical attitude pirogenal - phosphoserine - phosphoaminolipids - dicarboxylic acid. High biological activity P. associated with hydrophobic lipoidal And, while polysaccharide is hydrophilic media, contributing to the rapid penetration of lipoid in the tissues of the body.
P. administered intravenously or intramuscularly. At high doses P. fever persists for 6-8 hours. At the same time marked leukopenia, alternating with leukocytosis.
Sensitivity to action P. varies considerably in different people. So to start treatment P. recommended doses of 2-5 ug pro die, gradually increasing them, if after injection is not there has been a marked increase in temperature. It is established that the therapeutic effect of pyrogenal not depend on a rise in temperature, which can be seen as a side effect associated with the introduction of excessively high doses.
Pirogenal inhibits the formation of fibroblasts from young connective tissue cells, which leads to suppression of the development of scar tissue and contributes to reduction processes in the nervous tissue, increases the permeability of histo-hematic barriers, including the blood-brain, which helps to improve metabolism in tissues and the penetration of medical means in the Central nervous system. In this regard, P. used to stimulate and accelerate the process of rehabilitation of damaged Central and peripheral nervous system as after injury, and various diseases (poliomyelitis, encephalitis and other). P. contributes to the strengthening of the action of chemotherapy drugs, resorption of keloids after burns and injuries, and corneal opacities, adhesions in the peritoneum and strictures of the ureters, and urinary tract after surgery or infection. Promotes P. reverse sclerotic processes in the area of the middle ear. P. quickly stimulates fibrinoliticescuu blood system. So it is used for thromboembolic diseases. P. may also have a positive impact in bronchial asthma, psoriasis, eczema, photocontact dermatitis, a chronic diffuse streptoderma and other
Pirogenal as a drug used in the indications pyrotherapy (see) to increase nonspecific resistance of the organism (see) and improve the flow regenerative processes. Assign with syphilitic lesions of the nervous system, to accelerate the resolution of scars, including the burn scar the cornea with its opacity to stimulate recovery after diseases of Central and peripheral nervous system (polio, encephalitis and other). Enter pirogenal intravenously and intramuscularly; at last a way of introduction of pyrogenic action on do not pronounced, but the overall effect is maintained. Treatment of pyrogenal conducted courses lasting from 15 days to several months. The dose carefully individualiziruyut; in syphilis nervous system P. intramuscularly, ranging from 10 - 30 mg (0,00001 - 0,00003 g) with a gradual increase in dose to 80-150 g; for contractures and keloid scars start with about mcg, gradually increasing the dose to 20 mg, with injuries of the nervous system long impose on 0.5-5 g. P. contraindicated in acute febrile illnesses. The release form: ampoules to 1 ml with the content of P. as a sterile solution in 10, 25, 50 and 100 micrograms.