Pyruvic acid

Pyruvic acid (formula With3N4O3) - alpha-ketoprofena acid. Colorless liquid with a smell of acetic acid; soluble in water, alcohol and ether. Is used usually in the form of salt - pyruvate. Pyruvic acid is found in all tissues and organs and, being a link of metabolism of carbohydrates, fats and proteins, plays an important role in metabolism. The concentration of pyruvic acid in the tissues changes liver disease, some forms of jade, cancer, avitaminosis, especially the lack of vitamin B1. Metabolic pyruvic acid leads to acetonuria (see).
Cm. also the biological Oxidation.

Pyruvic acid (acidum pyroracemicum) - alpha-ketoprofena acid. There are two tautomeric forms - ketone and enol: CH3COCOOH→CH2→COHCOOH. Cecoforma (see keto acid) more stable. Pyruvic acid - a colorless liquid, smelling acetic acid, d -154 =1,267, temperature PL 13,6°, temperature Kip degrees (at 760 mm partially decomposed). Soluble in water, alcohol and ether. Nitric acid is oxidized in oxalic acid, chromic anhydride - acetic acid. As ketone SC gives hydrazone, semihydrate, oximes, and as acid forms esters, amides and salt - pyruvate. Used most often in the form of pyruvate.
SC produced by distillation of wine or grape acids using vodootnimajushchih means. Its definition is based on the reactions with nitroprusside, salicylic aldehyde, 2,4-dinitrophenylhydrazine whose products are painted.
Pyruvic acid is found in all tissues and organs. In human blood in the norm is 1 mg%, and in the urine of 2 mg%. The fortress played an important role in metabolism, being a link of metabolism of carbohydrates, fats and proteins. In the body of the fortress is formed as a result of anaerobic decomposition of carbohydrates (see Glycolysis). Further, under the influence of piruvatdegidrogenzu SC converted into acetyl-COA, which is used in the synthesis of fatty acids, acetylcholine, and can also transfer your acyl on salewoman acid for further oxidation to CO2 and H2O (see biological Oxidation). SC is also involved in the reactions of transamination and glycogenolysis.
The concentration of the SC in the tissues changes at various diseases: liver disease, some forms of jade, avitaminosis, spinal injuries, cancer, etc.
Metabolic SC leads to acetonuria.
In pharmacology pyruvic acid is used for making cinchophen.