Radiocative

Radiocative - method graphic registration of radioactive indicator through the cavity of the heart using a scintillation detector. The method and the term proposed in 1948 Prinzmetala (M Prinzmetal) and TCS. In 1954 Villas (N. Veall) and others found the possibility to calculate cardiac output (co) radiometeorologicheskijj curve. Further development of radiocative connected with the works of monastery (G. Monasterio) and Donato (L. Donato) with al., offered methods of selective quantitative radiocative.
Methodology: a radioactive tracer - J 131-albumin of blood serum (see Radioactive drugs) activity 20-100 mccoury quickly injected into the ulnar vein in the volume of 0.3-0.5 ml In the case of right-hand radiocative [definition of time pulmonary blood flow (VLK), the volume of blood in the lungs (OCPs), drums (PP), end-diastolic (MLC) and residual (g) of the volume and rate of discharge (CO) of the right ventricle] the drug is injected directly into the right atrium through a cardiac catheter. If you want to get the left-wing electoral radiocative to determine PP, BWW, NGO and FROM the left ventricle, the drug is administered through the pulmonary artery.
Radioactivity measurements made by the scintillator sensor installed above the centre precardiac region. When measuring the use of lead collimator with bore diameter 4 cm (2.5 inches) and a depth of 10 cm or 5 cm). The time constant of the ratemeter should not exceed 0.4 - 0.5 seconds. When determining MO speed paper recorder (oscilloscope) is usually 0.5 cm/s; in the determination of other indicators, it increased to 2.5 cm/sec. The deviations of the pen recorder the entire width of the paper (not less than 10 cm) must not be more than 0.5 sec.
Radiocalcium - RKG (ABCDE - Fig.) - consists of two overlapping one another curves "time - radioactivity". A segment of ABC is a registered part of the "right" of the curve, which terminates at the moment of appearance of the isotope in the left half of the heart (point C). Segment CDE is the sum of "the left)) curve (A B F) and final cut (CG) "right" of the curve. It also stops at the point E intracardiac recycling indicator. Extrapolation of segments of the armed forces and DE to the level of the background and then subtract CG cut a segment of CDF allow to receive the "left"curve A D f
After 10-15 minutes after registration RKG - upon reaching the uniform mixing J 131-albumin in the blood is on the tape recorder is logged level plateau balance over the area of the heart and the thigh at a constant time ratemeter 5-10 sec. At the same time is taken from a vein blood samples (5 ml), which together with 5 ml of standard solution (input J 131-albumin in a dilution of 1:500 or 1:1000) alternately placed in identical geometric conditions in the hole collimator. On the tape recorder is registered, the corresponding rate.

Radiocalcium after intravenous J131-albumin.

MO is calculated by the following formula (1):
where H is the height of the plateau equilibrium above the heart area (mm); H' - the same over the hips (Ile); S - the rate of a standard solution (mm); - the same blood samples (mm); (D - dilution factor of a standard solution; J - entered the volume J131-albumin (ml); - speed of movement of a tape recorder (mm/min); And - the area under the curve ABCDEF measured by planimetry (mm2).
OK MO ranges from 3.4 to 8.4 l/min, falling to 1.8 and 3.3 l/min in severe heart failure.
For calculation of hemodynamics of the right ventricle and light on the oscilloscope at the same time with RKG registered and ECG. MO determined as described above. Averages for each of the cardiac cycle the values of the count rate of the descending part of the "right" of the curve, calculated after correction for damping chain RC ratemeter, are transferred on semi-log paper (per unit of time on the x-axis is taken cardiac cycle). The amendment to the damping is paid according to equation (2):
where Yt is true, and Rt - registered rate of account; T - time constant analog meter.
WITH calculated according to the formula (3):
where Y0 is the initial (maximum) rate above the right ventricle, Up - count rate above the ventricles through and cardiac cycles. Knowing and WITH the MA (quotient of the MOE on the number of heartbeats in 1 minutes), you can calculate BWW and CBOs (formula 4 and 5):
To determine VLK and OCPs method Donato need General RKG spread out in semi-logarithmic scale on the "right" and "left" curves and determine the values (in cardiac cycles) t0 is the time to begin removing isotope from the right ventricle, tа - time of the first appearance of the indicator in the left half of the heart and tп - time peak of the "left" of the curve. Average BJ1K is obtained from equation (6):
VLK= cardiac cycles. (6)
The value of OCPs in turn is equal to (7): the OCP = VLK·PP. (7)
Normal average values of hemodynamics of the right ventricle and pulmonary following: CO - 42,5 ±3.8% for the systole, PP - 92±19 ml, MLC - 220 ± ±49 ml, 00 - 128±32 ml, OVER - 5,97± 0,83 cardiac cycle, the OCP - 546± 104 ml
Hemodynamic parameters of the left ventricle are calculated according to formulas (2, 3, 4, 5) from the curve obtained after the introduction of the indicator in the branch pulmonary artery or directly into its cavity. A new method of analysis RKG allows for a General curve registered after the injection of the isotope in the right atrium, calculate the constants of the right and left ventricles (Donato and others). The authors received in 14 healthy people following values of hemodynamic parameters of the left ventricle: FROM - 50 ±5% for the systole, BWW - 182±31 ml, g - 92,3±21,5 Jr.