Pathological anatomy of pancreatic cancer

The size of the tumors can be various, but usually do not reach a large size, which makes them difficult to palpation. Large tumors are usually found at the tail of cancer in the left hypochondrium and palpation mistaken for an enlarged spleen.
The original place of cancer growths are the epithelium of the excretory ducts of the pancreas, Ainslie and Centralnoye cells and, rarely, the cells of the islets of Langerhans. The most common form is a cancer that originates from the epithelium of the excretory ducts. If the tumor is accompanied by the growth of connective tissue, formed skirr. Macroscopically, the latter can be adopted for chronic pancreatitis and fibrosis. If the tumor is dominated epithelial tissue, which happens more often, it has a soft texture, gives rapid growth, achieve in a short time of significant size and it may have a softening in the center. When cancer that originates in the epithelium ducts and Acinonyx cells of the islets of Langerhans, as a rule, for a long time remain unaffected. This explains the possibility of the absence of obvious violations in carbohydrate metabolism even with advanced cancer of the body. Cancer arising from the islets of Langerhans, is rare. He usually localized in the tail or on the border of the tail and body of the pancreas.
Around the tumor signs occur reactive inflammation with symptoms of fibrosis. Growing, cancer can move to the neighbouring organs: the back wall of the stomach, liver, spleen, left kidney and cross the colon. Depending on the location of the tumor latter can compress the common bile duct, portal vein, the inferior Vena cava, the solar plexus, mesenteric plexus, General lymphatic duct, duodenum and, finally, ducts inside the pancreas.
Pancreatic cancer often spreads. This most commonly occurs when cancer of the tail, in connection with a longer course of the disease. Metastases are found in the lymph nodes, lungs, liver, the mesentery, the adrenal glands and other organs.