Welt-illness". runt disease - the disease stunting rate") develops in newborn animals after transplantation them during embryonic development or during the neonatal period homologous blood-forming tissues from adult organisms. First described in 1957 by Simonsen, Billingham and Brent (M. Simonsen, R. E. Biilingham, L. Brent).
The mechanism of development of pathological process caused by several things: the immunological immaturity of the fetuses, and newborns organisms, due to which the alien transplant cannot be rejected; the ability of transplanted cells to engraftment and reproduction; the presence of transplanted tissue immunologically active lymphoid cells. Colonization of donor cells of the organism immunological inert newborn ends of the immunological reaction of the transplanted cells against the tissues of the recipient (graft versus host").
Syndrome Welt-disease consists of several typical manifestations: 1) the lag in growth and development, drastic, diarrhea; 2) dermatitis with lesions of the skin appendages; 3) a sharp disturbance in the blood system: proliferation, and then atrophy of lymphoid tissue, anemia, focal necrotic changes, expressed splenomegaly. Death occurs in 2-3 weeks. The increase of the splenic index - relations weight spleen (mg) body weight (g) - considered one of the most telling signs Welt-disease. OK splenic index is less than one, at the Welt-disease it is 2 - 3.