The reaction of connecting elements of the liver

The reaction of connecting elements of the liver is more likely to occur as secondary in response ia hepatocellular injury, but may be of primary, caused by a virus or other agent (Popper, Schaffner, 1957, 1965; A. F. of Bluger and others, 1970). A significant fact that stimulate the proliferative activity of the connective tissue that serves as hypoxia liver tissue (M. N. Khanin, 1964, 1968).
This reaction is revealed in the activation and proliferation of endothelial cells and in education vnutriposelkovykh and periportal infiltrates. Active kuperovskaya cells is increased in size, rounded, the kernel also increased, cytoplasm significantly basophilia and contains a large number CHIC-positive substances. According to Bark and Schaffner (1963), for active endothelial cells characterized by high activity of acid phosphatase in their cytoplasm, that, obviously, due to a significant increase in the number of lysosomes. Atargas in the lumen of sinusoidal, kuperovskaya cells can clog them that entails focal ischemic necrosis. Kuperovskaya cells are actively involved in the phagocytosis. They are transformed and fibroblasts, actively producing collagen fibers (the A. F. of Bluger with al., 1970).
Abnormal cell infiltration portal fields (Fig. 56) from physiological moderate infiltration is more intensity and combined with dystrophic changes in the parenchyma. With active chronic hepatitis cell infiltrates penetrate into slices, isolating in periportal zones individual hepatocytes, accompanied necrobiotic changes of the recent (Popper et al., 1960).

Fig. 56. Inflammatory infiltration portal tract. Explanation in the text,

These infiltrates usually represented by mononuclear cells, sometimes in bacterial inflammation - polinucleari. A. F. of Bluger et al. (1970), Popper and others (1965) note that many forms of mononuclear cells involved in cell immunity (lymphocytes, monocytes) or related products globulin (plasma cells) and are important in the implementation of the pathological process. A. F. of Bluger and N. Veksler M. (1968) found that such a proliferation of cellular elements accompanied by marked immunological changes and causing secondary damage to liver cells.
It is known that many pathological processes in the liver lead to increase of connective tissue in it and eventually to fibrosis. Significant areas of connective tissue can be formed on the place of necrosis of the liver tissue caused spadenia reikalingas network, and then kollagenaza fibers - the so-called collapse-fibrosis (Popper, Schaffner, 1957). In addition, essential increased the formation of collagen fibers fibroblasts, including activated mapfromscene cells (Perez-Tomayo, 1965; Schnack and others, 1967).
Possible and extracellular education connective tissue of parametricheskikh substances, in particular through depolymerization muhidnova substances. The accumulation of the latter is due to metabolic disorders and hypoxia, always available at long suffering liver. The results of studies K. S. Mitin (1969) and B. D. Damyanova (1970) suggest that connective tissue membrane inside the segments are formed from moving at a distance of makromolekul of tropocollagen. The latter are the product activation fibroblasts. In particular, for chronic hepatitis due to this mechanism in the space of the thesis appears connective tissue, forming the basement membrane, than due to the so-called capillarization of sinusoidal (Popper, 1962).