Cross reactions to cow milk protein

Goat milk
If you are allergic to milk, cow milk is often replaced goat. Hill [34] examined 45 children under the age of 2 years with eczema, have had a positive skin test for mad cow lactalbumin; 25 of them skin tests and goat-lactalbumin were positive, and 10 - doubtful, what is the frequency of cross-reactions.
Saperstein [35] gives the following evidence similarities antigenic properties of proteins in cow's and goat's milk:
1) antisyware to bovine beta-lactoglobulin, alpha-lactalbumin gave positive precipitation of protein whey goat milk;
2) rabbits were sencibilisiruet small amount of protein in cow's milk and for several months did not have antibodies. Introduction to the rabbit whey protein goat milk led to anamnestic response, increased education antibodies to cow milk proteins;
3) in Guinea pigs, which was passively sencibilisiruet to: cow milk proteins by single intraperitoneal injection of specific antisera, developed anaphylaxis after allowing intravenous infusion over 1 to 2 days of serum proteins goat's milk.
Crawford and Grogan [37]using the method of double diffusion, in the gel [Ouchterlony 36]found that goat alpha-casein, beta-lactoglobulin, alpha-lactalbumin immunological similar to the appropriate fractions of cow's milk, and the lines precipitation for casein were almost identical. According to Jeness et al. [38], antibodies to bovine beta-lactoglobulin react with beta-lactoglobulin cow, sheep, goat and Buffalo milk.
According to the clinical studies [28, 29], children with Allergy to cow's milk is often respond positively and try goat's milk.
   Sheep milk
Beta lactoglobulin cow's and sheep's milk was investigated using the method of double diffusion into agar and immunoelectrophoresis using rabbit antiaborto to both types of beta-lactoglobulin. Both protein gave a cross-reaction with two types of antisera [5]. It is possible that the molecular structure of cow and sheep beta lactoglobulin so close that the body of a rabbit responds to these proteins are the same, and produced antibodies are identical. Apparently, cross-reactions typical for beta lactoglobulin most ruminant animals.
Cow hair
A clinical study conducted by Osvath et al. [30], indicates the presence of cross-reactions between proteins in cow's milk and cow's hair. Were surveyed 10 children with bronchial asthma as a result of consumption of cow's milk. After the test bronchial irritation cow hair, 7 of them have developed bronchospasm. These data suggest that allergens are whey proteins, because they are found in cow's milk and hair.
Breast milk
The proteins in cow's milk, apparently, do not provide cross-reacts with proteins in breast milk [40-42]. However, some whey proteins person resemble the respective bovine serum proteins found in milk, and to cross-react with them when using rabbit antisera [17]. The value of these cross-reactions to the clinic remains unclear.