Immune reaction to cow's milk proteins in patients with a heightened sensitivity to milk

Since the formation of antibodies to cow milk proteins is a normal reaction observed in healthy people, it is a natural question: is there a difference between immune responses to proteins in cow's milk in sensitive to milk persons in healthy people? The answer to this question is different, but in certain circumstances. Some are sensitive to milk patients tend to the formation of antibodies to cow milk proteins in higher title than that of healthy, but it is not enough reliable indicator so that it can be used as a diagnostic test. Between antibody levels and symptoms of the disease may not be a direct connection. According to Fallstrom et al. [9], such a dependence is easier to identify when to evaluate several classes of antibodies. This approach to the diagnosis is still in its infancy, and its success will depend on improvement of laboratory methods.
A hypersensitive reaction to cow's milk proteins, as well as for other foods, undoubtedly include not one immunological mechanism. Some types of hypersensitive reactions associated with primary education one of the classes of antibodies, such as IgE antibodies. In other cases, the immune response may be mediated mostly by the reaction of the cell, not humoral type.
When using the method of double diffusion into agar at microslide discovered multiple Lines precipitation (typically five or more), formed in the reaction between antigens cow's milk and antibodies in the serum of patients with the syndrome, caused by the intake of milk; this syndrome include chronic lesions of the upper and lower respiratory tract and sometimes gemosideros lungs [20-22]. This group of patients was examined Holland et al. [23], who noted that the symptoms of respiratory failure and the presence of precipitin to proteins of milk can be accompanied by enlargement of the liver. In the group of children with Allergy to cow's milk and lesions of the gastrointestinal tract half of the surveyed found a high titer of hemagglutinin and precipitin [24].
In the serum of patients with gastrointestinal Allergy to milk more often find antimalaria precipitin, not reagents [15-25]. Collins-Williams and Salama [26] noted that the reaction of precipitation and passive cutaneous anaphylaxis were more positive in sensitive to milk the sick, than the control group; the results of the reaction of haemagglutination were similar in both groups.
The content of dairy precipitin of hemagglutinin and rarely increases with classic symptoms, atopy, caused by the intake of cow's milk [27-29]. In allergic diseases, as a rule, find IgE antibodies class. The most valuable tests identify and rough quantitative assessment of IgE antibodies are scratch and intradermal tests, radioallergosorbent test (RAST), release of leukocyte histamine, radioimmunotherapy and the method of cross-radiommunodetection.
There are data indicating the possibility of participation of complement in some form of Allergy to cow's milk [30, 31]. There is also a direct effect of some proteins food to complement [32].
In recent years, there is evidence that certain Allergy to cow's milk may be due to immunological reactions of cell types, the role of which is very important. Scheinmann et al. [33] in experiments in vitro was investigated lymphoblastic transformation of 45 patients with gastrointestinal Allergy to milk. Positive results were obtained in 17 patients (38%): 8 - beta-lactoglobulin, 7 - alpha-lactalbumin and two - with both proteins. Many authors have investigated the formation of lymphokines along with lymphoblastic transformation and in some cases received positive results [34-37A]. The accuracy of the method of research products limfokinov will increase if radioimmunoassay or specific chemical methods will replace the currently used biological methods.
In addition to the above immune reactions, allergies to cow's milk may also be caused by the presence of short-lived IgG antibodies, the formation and deposition complexes antigen - antibody release of chemical mediators and modulators, such as prostaglandins, kallickrein, the factor of Haymana and other