Regulation of menstrual function

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Neurosecretory cells have, on the one hand, the inherent normal nerve cell features to perceive and to transmit nerve impulses, and on the other, are able to produce secrets (neurohormones) and to single them. Monitoring vital functions neurosecretory cells shows that in the cytoplasm it possible to determine the presence of the so-called Gomory-positive (painted by Gomory) pellets. Pellets consist of lipoprotein and gipoglikemicakih complexes that form the core of granules, concluded in a phospholipid membrane; the size of granules ranges from 500 + to 1.5 microns in diameter. In the production of pellets is of particular importance kernel neurosecretory cells, because the primary processes of the formation of Nanocrete begin either in the kernel or close to it. The process of formation of Nanocrete very fast and intense.
Allocation secret of neurosecretory cells, as in the glandular cells of epithelial origin, due to the increase of the volume of the cytoplasm and nucleus, in which accumulate granules, and then celebrated their displacement in the axon, which leads the cytoplasm to the devastation. Actively secreting nerve cell greater in volume than at rest (C. C. Zhukova, 1969). Transportation of Nanocrete on AXONE done with great speed, but this is not the only way of giving Nanocrete as possible the transition to the pituitary gland and vnutriepetelialnaya education not only for conduction paths, but also by contact with ependymal third ventricle, blood vessels, with glandular elements. The concentration of Nanocrete in the mesial Eminence.
Given the role of hypothalamic secrets affecting gormonoobrazovanii functions in adenogipofiza, it is customary to distinguish between them in two genera. Some of them are named after releasing factors (RF) due to the ability to enhance, encourage the return of pituitary hormones, others, on the contrary, weaken this bestowal, oppressed her, and named inhibiting factors (IF).
The summation of data on presence or absence of activating or oppressive function adenogipofiza hypothalamic substances produced B. C. Aleshin (table. I).

TABLE 1. Hypothalamic (adenogipofiza substances B. C. Aleshin. 1971)
Pituitary hormone Activating factor Depressing factor

Somatotropin
Adrenocorticotropic hormone
Thyroid-stimulating hormone
Follicle-stimulating hormone
Luteinizing hormone
Luteotrophic (lactotrophs) hormone
Melanocytestimulating hormone

+
+
+
+
+
?
+
+
?
-
-
?
+
+
Legend: ( + ) - evidence of undeniable factor; (-) - proof of the absence of the factor certain; (?) - evidence of the presence or absence of factors questionable.

The exact chemical composition of hypothalamic secrets into force negligibly small quantities to install failed, but their protein nature is doubtless, the proof of which is the synthesis of Tripeptide (Igarashi, 1971), providing the pituitary effect, similar RF - FSH.
The currently developed methods of determining the RF; they are based on cleansing and fractionation of blood plasma of women with further testing on animals.
The factor that activates the impact of follicle-stimulating hormone (RF - FSH), allocated Igarashi and Msapp in 1964, it clearly proved its catalytic role in the development of follicles in the ovary. Found that the number RF - FSH are in accordance with the allocation rates of estrogens and FSH, which proves the undoubted starting role FS - FSH in respect of follicle-stimulating hormone in the pituitary gland and the subsequent already pituitary impact on gonads.
Nikitowitch-Winner (1962), J. M. a Tavern and E. Vsokolov (1962) found that extracts from the medial eminencia cause ovulation in animals. This effect is observed when the transection of the leg of the pituitary gland, but absent in gipofizektomii animals. The use of the extract induce ovulation even in animals that are in a drugged sleep and having permanent estrus against the background of persistent follicles. Its application causes an increase in the level of LH in the blood, which allows us to call it a factor that activates the impact of luteinizing hormone (RF - LH).
During astral cycle is marked increased allocation of RF - LH end distrainee phase and thus prepared ovulation (Sawyer, Everett, 1959). Found that between luteinizing function of the pituitary gland and stimulates the activity of the hypothalamus exist feedback, which result in the accumulation of LH leads to decreased secretion of RF - LH.