Reticuloendothelial system

Reticuloendothelial system (synonym: RES, the system of macrophages) - system cells scattered in different parts of the body, carrying barrier and phagocytic function and the function of metabolism. Bodies of special concentration cells RES are spleen, lymph nodes and bone marrow.
As the main building blocks of the REFs are histiocytes (tissue phagocytes, macrophages), the proposed various symbols of this system is reticulohistiocytosis system, macrophages.
The cells of the RES are: reticular and endothelial cells of the lymph nodes, spleen, liver, bone marrow; the cells of the outer shell (adventitia) blood and large lymph vessels; kuperovskaya liver cells; histiocytes loose connective tissue macrophages. Properties, uniting all these cells into a single physiological system are: 1) the ability to absorb and accumulate in the cytoplasm of a variety of substances suspended in the blood; 2) close to this ability is the ability of the cells of the RES to phagocytosis, i.e. to the active capture and intracellular destruction (or long-term storage and subsequent disposal) of pathogens; 3) participation of the RECs in blood: a) intracellular the destruction of obsolete blood cells with subsequent use of products of destruction and b) the formation of blood cells for which the source of the parent cell is reticular cell (see Blood, Blood); 4) active participation in the reactions of the immune system (see) by the formation of antibodies (see) in the cell derivatives RES; 5) participation in intermediate metabolism, what determines the full name of this system is the reticuloendothelial system interstitial metabolism.
RES is an active mesenchymal (cambial cellular reserve of loose connective tissue), retaining its reactive ability in adult organism. RES is activated by pathogens, resulting in duplication (proliferation) of cells of the RES and the change in their structure and chemical composition of cytoplasm.
From the degree of activity and reactivity RES depends on the outcome of many, especially of infectious diseases.