Schiff's base

Schiff bases (N. Schiff) connection has its molecules group = C-N-R discs.
Schiff bases are formed; 1) when the interaction of aromatic aldehydes with aniline: C6H5-NH2+O=HC-C6H5→C6H -5-N=CH-6N -5+H2O;
this reaction is reversible and in acidic solution Schiff bases hydrolytically split; 2) in the process of synthesis of secondary amines nitrile restored to aldimine, which is then partially hydrolyzed to aldehyde, and partially restored to primary amine; the resulting substances interact with the formation of Schiff bases; 3) direct interaction aldimine with primary amine; 4) when heated secondary amines with hexamethylenetetramine in the presence of acetic acid; 5) in the synthesis of aldehydes from Annelida, accompanied by the formation of Schiff bases (salt) as an intermediate product; 6) as the intermediate in the synthesis of amino acids aldehydes; aldehyde, interacting with ammonia, forms aldehydic that, Tsaplya water turns into appropriate Schiff base.
Amino acids form Schiff bases with aldehydes and other compounds containing carbonyl group. A role of Schiff bases attributed in enzymatic catalysis. Dipeptidase and aminopropiophenone act on the substrate only if he has a free amino group with which these enzymes are bound, probably through their carbonyl groups, forming Schiff bases. Similarly interaction coenzymes transamination with substrates: postperinatal with amino acids (through the amino group) and posterization with keto acid (via ketogroup).