Shvartsman phenomenon

Shvartsman phenomenon (G. Schwartzman) is a local manifestation of a kind of toxico-allergic reactions that occur with repeated exposure to excreta of some microorganisms susceptible to allergies animals. This phenomenon is connected the appearance of a hemorrhagic phenomena with infections assume its part in the mechanism of some organ lesions, such as acute rheumatic fever.
Primary intradermal injection of filtrate of culture of typhoid bacilli (sensitizing dose) usually does not cause any local reactions. However, if you enter the same intravenous antigen in 24 hours (resolution dose), in place of the previous injection 1-2 hours will have a strong venous hyperemia, which turns into a hemorrhage, and then in necrosis. There are capillary stasis, thrombocytopenia and bleeding disorders. Found that this effect is played, and then when the resolution injection impose some non-specific substances: sera of certain animal species, agar, pyrogenic funds.
Nature and pathogenesis of the phenomenon Shvartsman is not fully disclosed. It is shown that because of the reduction in clearance and damage of vascular endothelium in the primary action of microbial toxins develops the state of local hypoxia, accompanied, by a buildup of lactic acid, as in the capillaries of the damaged site accumulate polymorphonuclear leukocytes. At intravenous resolution injections in anoxemia areas accumulate new masses of white blood cells and platelets, leading to thrombosis, and vascular necrosis of the cells and haemorrhage. Along with local events after the resolution doses may occur General - growing hypothermia, convulsive seizures with asphyxia and death.
Found that the development of generalized phenomenon Shvartsman in rabbits caused by precipitation of whey proteins inside blood vessels and the possibility for passive transfer of sensitivity serum way. The development of the phenomenon Shvartsman can be prevented by following the resolution injection to type anticoagulants, such as heparin. Cm. also Allergic.