the LPVLPV (Secale cornutum, uterine horns) - fungus, parasite of some cereals, mainly in the rye. Drugs LPV have a strong stimulating effect on the muscles of the uterus and yet have adrenolytic properties, which, however, is not enough expressed because of the strong vasoconstrictor action associated with the direct influence of ergot alkaloids on the walls of blood vessels. Adrenolytic action of ergot alkaloids is greatly enhanced by a change of their chemical structure, resulting in digidrirovanny alkaloids (see Digidroergotamin, Digidroergotoksina).
Drugs LPV and its alkaloids prescribed for atopic metrorrhagia, menorragiah, spasm of the vessels, and hypertension.
In obstetric-gynecologic practice, the most widely used drugs of the main alkaloids LPV - ergometrine and ergotamine.
Ergometrine produced in the form ergometrine maleate (Ergometrinum maleicum, Ergometrini maleas; list B). Appoint parenteral 0.0002 g and inside of 0.0004 g 2-3 times a day. Dosage form: tablets containing 0.0002 g ergometrine maleate and ampoules to 1 ml of 0.02% solution. Keep in dark place at a temperature of no higher than 10 degrees.
Ergotamine produced in the form of ergotamine gidrotartrata (Ergotaminum tartaricum, Ergotamini tartras; list). Compared to ergometrina is more protracted. Assign inside 10-15 drops of 0.1% solution 1-3 times a day or parenteral 0.5-1 ml of 0.05% solution. Treatment for 7 days. Method of production: ampoules to 1 ml of 0.05% solution, the vials of 10 ml 0.1% solution, tablets 0,001, Keep in dark place at a temperature of no higher than 10 degrees.
Erhotel (Ergotalum; list B) is a mixture of phosphate alkaloids LPV. Assign inside 1/3 - 1 tablet 2-3 times a day or under the skin and in muscles at 0.5 to 1 ml of the Form: tablets containing 0.001 g the amount of alkaloids, and ampoules to 1 ml of 0.05% solution.
With long-term use drugs LPV, and also by eating cereals, infected LPV, may phenomenon ergotizma, expressed in a spasm of blood vessels and malnutrition tissue (especially limbs), and mental disorders.
Contraindications to the use of ergot: pregnancy, childbirth, the presence of child seats in the uterine cavity, koronarospazm.
Cm. also Uterine funds.