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The discovery of streptomycin has considerably expanded opportunities of antibiotic therapy and opened new ways in chemotherapy of tuberculosis.
Soviet scientists N. A. Krasil'nikov, M. I. Nakhimovsky, A. I., Korenyako and Y. A. Borodulin back in 1935 found that radiant fungus-actinobacteria have antagonistic properties.
In 1944 3. Waxman in the USA allocated from the soil radiant fungus, which is in the process of life forms antibiotic called streptomycin.
Streptomycin has a broader spectrum of antibacterial action than penicillin. That is, in other words, it operates on a larger number of groups and species of bacteria. Thanks to these valuable properties of the drug are widely introduced into clinical practice.
Currently, for intramuscular used hydrochloric acid, sulphate, streptomycin, and for introduction into the spinal canal - crystalline complex Sol streptomycin with chloride calcium.
In recent years, the widely used dihydrostreptomycin - product recovery of streptomycin. Some patients the drug tolerate this better than streptomycin. Indications for use of dihydrostreptomycin the same as streptomycin.
Streptomycin is a highly effective antibacterial agent. Especially brilliant successes achieved in the treatment of this drug meningitis - diseases which earlier led inevitably to death. If streptomycin enter from the first days of the disease, it is possible opasti up to 80 percent of patients.
Streptomycin is successfully used for tuberculosis of the lungs, bone tuberculosis, tuberculosis of serous and mucous membranes, in tuberculous disease of the eyes and skin. Streptomycin has increased the surgery the most severe forms of tuberculosis of the kidneys, lungs and other
For treatment of tuberculosis streptomycin and dihydrostreptomycin have to apply for several months, and during this long-term use of bacteria acquire resistance to streptomycin is much faster and more frequently than in the treatment of penicillin. This ability of microbes to get used to, to adapt to this drug and lose their sensitivity to it reduces its value. Have streptomycin and another drawback: it may cause in the body some side effects are - dizziness, headache, hives, dermatitis. One of the most serious complications - effect on the Central nervous system. It shows through in the form of a decrease in hearing and disturbances. So now widespread method of streptomycin in combination with other chemotherapeutic agents, PASK (paraaminosalicilovaya acid), tibon, salyuzid, ftivazide. With this method, on the one hand, hampered the development of streptomitsetov forms tubercle Bacillus, on the other, shall be abolished completely or partially the side effects caused by drugs, as well as with the combined method of treatment daily dose and obscurenova dose of antibiotics is significantly reduced.
Streptomycin has been effective not only in TB control. This wonderful antibiotic cures such terrible diseases as plague, pestilence which still are in some foreign countries. When pulmonary form of the plague after the introduction of the antibiotic is recovering 90 percent, while the bubonic - 100 percent of patients. In many cases, 10 grams of streptomycin in order to save him from death.
In the treatment of cholera, and the cases of it are in some Asian countries (India, Pakistan), the combined use of streptomycin with alpazolam or sulgin and bacteriophage gives a good therapeutic effect.
Streptomycin is used successfully for the treatment of tularemia, brucellosis, urinary tract infections caused by Escherichia coli or penicillinonline Staphylococcus, with meningitis. As penicillin, streptomycin is used in surgical practice in the treatment of sepsis, suppurative diseases of the pleura and peritonitis.