Sulfa drugs

Sulfa drugs - derivatives sulfanilic acid, which has antimicrobial properties.
Sulfa drugs have a broad spectrum antimicrobial action. They have a bacteriostatic effect against streptococci, staphylococci, pneumococci, enterococci, meningokokkov, gonokokkov, coliforms, sticks dysentery, typhoid, protozoa (malaria parasite and Toxoplasma), major viruses (trachoma, psittacosis , and others), some aktinomicetov, V. cholerae and other
Antimicrobial effects of sulfonamides are mainly associated with the violation of the process of obtaining microbes necessary for their development, growth factors of folic acid and other substances in the molecule of which is para-aminobenzoic acid.
According to their ability to absorb and stand out from the body sulfa drugs are divided into 3 groups: 1) rapidly absorbed and rapidly excreted kidneys (see Norsulfazol, Streptocide, Sulfadimezin, Sulfazin, Sulfatsil, Prosulpin, Etazol , and others); 2) long-term actions (see Sulfapiridazin, Sulfadimetoksin, quickly absorbed and slowly released from the body that allows you to assign them 1 time per day; 3) poorly absorbed from the gastrointestinal tract (see Desultory, sulgin, Ftazin, Ftalazol). Due to the fact that these sulfa drugs creates high concentrations in the gut, they are shown at enteritis, colitis, bacillary dysentery.
Sulfa drugs used for angina, pneumonia, streptococcal and staphylococcal sepsis, meningitis, acute intestinal infections, pustular skin lesions, inflammation of the urogenital tract, psittacosis, trachoma, deep mycosis and others, as well as for the prevention of complications during surgery.
Some sulfonamides are used in the form of solutions for parenteral introduction, as well as for local use in solutions, powders, ointments, liniments, suppozitoriev.
In the treatment of sulfa drugs may experience side effects as nausea, vomiting, headache, dizziness, skin rash, drug fever, leukopenia. The development of side effects reduce the dose, and, if necessary, stop taking the drug. Relatively often have impaired kidney function. Due to poor solubility sulfanilamida and especially their acetylated products may fall in the kidneys in the form of crystals (crystalluria). To prevent this complication designate a rich alkaline water. May be the development of microbial resistance to sulfa drugs.
Contraindications to the use is increased sensitivity to sulfa drugs. At diseases of blood system, disorders of the kidneys, liver disease, cardiac decompensation activities sulfa drugs prescribed with caution.