Suppression of the immune response in cancer

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Along with T-suppressor cancer is accompanied by the appearance of B-suppressors. They arise soon after transplantation syngeneic leukemia cells and then migrate to the bone marrow (I. G. Sidorovich, R. M. Khaitov R.M). Ability to activate suppressor lymphocytes have only a live tumor cells. Repeatedly noted the emergence of a suppressor of macrophages in animals with a transplanted tumor.
Macrophages-suppressor produce prostaglandins - hormone produced in very small quantities not glands of internal secretion, and various cells. Especially noticeable suppress the immune system prostaglandins group E2 (PGE2). It is noteworthy that cancer cells, especially bystrogasjashchajasja are also producers of PGE2. Obviously, the cells of malignant tumors should have a variety of immunosuppressive potentialities - close-applicable to disable neighboring regulatory lymphocytes and macrophages and distance to weaken generalized T-immunity. The synthesis of PGE2, apparently, is one of the most important local suppressor tools tumors. Proof of this is the observation that the property to the production of PGE2 most pronounced exactly the cancer stem cells compared to their descendants. With the help of PGE2 parental cell tumors disarm the EC-cells, cytotoxic macrophages. Moreover, they "impose" the synthesis of PGE2 by macrophages, as if putting them in a category of their "accomplices", not strengthening and weakening local immunity. This PGE2 is not the only immunosuppressive factor, the SJC as some substances can inhibit the production of prostaglandins (aspirin, indomethacin), but no tumor growth.
Remote factors immunosuppression are T cells, suppressor immunosuppressive or blocking serum mediators. About biological origin past, there was a lot of assumptions. To lock products dissolved in the blood plasma, attributed antibodies of IgG class, the molecules themselves tumor cells (i.e. soluble tumor antigen), a complex of antibodies to the antigen. We have made the suggestion that it is soluble mediators of lymphocytes-suppressors. However, the discussion is not yet completed. It is unclear finally and whether to put a sign of equality between the blocking factors and immunosuppressive substances in the blood serum. The term "blocking factors" was introduced in 1971 spouses Ingrid and Carl Hellscream who first noted the ability of serum of the animals with tumors to eliminate the damaging effect of own cell tumor target cells. The term immunosuppressive factors" got citizenship after approval of a new class of lymphocytes, which prior to the beginning of the same 70-ies and not guessed, we are talking about T-suppressors. You can still conditionally to make the following distinction: blocking factors are nonspecific oppressors reactions cellular immunity, immunosuppressive factors, there is greater specificity of action. From these positions PGE2 refers to blocking agents as a blocking antibodies to immunosuppressive.
Blocking whey products are available and during normal pregnancy, moreover, the disappearance of serum blocking substances usually precedes pathology (for example, in case of spontaneous miscarriages). Pregnant activators of these properties serum serve as antigens tissue compatibility of the fruit of his father's origin. If we compare this situation with the development of a tumor, you should agree that blocking substance depend on the antigenic properties of the tumor. When pregnancy is blocking factors disappear from the bloodstream immediately before delivery, quick neutralization is achieved hormonal products. In tumor growth physiological neutralization remote serum blockers is not happening. They weaken after surgical removal of the tumor mass and increase in the recurrence of the disease.