Syphilis

Syphilis (lues) is a chronic infectious venereal disease caused by a pale Treponema and affects the entire body of the patient.
The etiology and pathogenesis. Pathogen - pale Treponema with the appearance of a thin spiral filament length of 6 - 7 MK fine uniform curls number from 8 to 12.
Living Treponema easiest can be detected by microscopic examination drops detachable hard chancre or weeping papules (see below) in a darkened field of view with typical movements: rotational, flexion, pendulum-like, moving forwards or backwards. Outside the human body of Treponema live and retain infectivity in a wet environment, for several hours; they quickly die at drying, with heating (at temperature 55 degrees for 15 minutes), under the action of detergents, acids, alkalis; for cooling, they are less sensitive: when freezing remain viable within 2-3 days, and this explains cases of infection with syphilis from a corpse.
The possibility of infection with syphilis animals proved for the first time in experiments on monkeys (Mechnikov and Ru).
Currently, experimental study of syphilis spend mainly on rabbits.
Infection with syphilis occurs in close contact healthy person with sick with infectious syphilis symptoms, or through infected subjects. The most common route of infection is sexual; infection occurs when the kiss, bite, when using a toothbrush, a spoon, cigarette, etc., which until then had enjoyed the patient.
The most dangerous in respect of infectiousness of the manifestations of primary and secondary periods of syphilis. Manifestations of late tertiary period considered practically non-contagious because of the small number found in them treponem.
Source of infection may be the blood of a patient with syphilis (transfusion syphilis transmission of blood donor).
Household infection with syphilis are observed mainly among population backward economically and culturally countries. Pale Treponema penetrate the skin or mucous membrane through the smallest scratches, cracks, etc., With the penetration of pale treponem in the body occur complex changes of physicochemical and immunobiological character.
During incubation and initial period of illness pale Treponema distributed to all tissues and organs. Possible follow (after treatment) infection, syphilis, as persistent immunity is not formed.
The clinical picture is characterized by alternating periods of active manifestations (active syphilis) and hidden (latent syphilis). Clinical manifestations of the disease gradually take more and more pronounced, including serious irreversible changes (skin, internal organs, the Central nervous system) in the later stages of the disease.
In the course of syphilis distinguish incubation, primary, secondary and tertiary periods.
The incubation period (from the time of infection until the first signs of the disease) lasts an average of three to four weeks; he can have a greater duration (60 days or more) in cases when the patient because of a disease in this period was applied penicillin or any other protivoepilepticheskie funds; in rare cases it can last only 10-12 days.

  • The primary period
  • Secondary period
  • The tertiary period
  • Diagnosis of syphilis
  • Treatment of syphilis
  • Congenital syphilis
  • Public prevention of syphilis