The effect of combinations of drugs to dental caries

Our research and literature data show that not all drugs act on the caries of the teeth the same way. There are more active, less effective and the so-called neutral. It was also noted that a good anticariogenic effect by local applications in the form of pastes have phosphate, mixture of phosphate fluoride, sea Kale and other combinations of drugs. In particular, were selected drugs which, according to our data, was the most effective. Combined, as a rule, the drugs that have different physiological effects, such as vitamins and phosphate, phosphate, and sodium fluoride, etc., In some cases combined local and endogenous action, i.e., gave animal products from the diet, and also conducted the processing teeth rats special pastes made from these elements.
Have been investigated the following combinations of drugs: vitamin B1 and sodium fluoride in drinking water, vitamin D2 and glycyrrhizinate of calcium in the diet, vitamin B1 and glycyrrhizinate of calcium in the diet, vitamin B6 and glycyrrhizinate of calcium in the diet, glycyrrhizinate calcium and marine cabbage diet and pasta, glycyrrhizinate of calcium in the diet, sodium fluoride in drinking water and pasta. The last two groups of rats conducted daily tooth special pastes made from compositions, which included glycyrrhizinate calcium fluoride sodium or glycyrrhizinate and seaweed. This, in our opinion, should achieve the best effect due to the combination of endogenous and local impacts.
In a series of experiments were studied in 8 groups of experimental animals (247 rats "Vistar"), receiving various combinations anticariogenic additives, including two groups of the control rats.
Negative influence on teeth caries was most different groups of animals. Common to all animals is relatively low prevalence of dental caries in both the number of teeth affected, and the number of carious affects. Higher rates of morbidity teeth preserved animals treated with vitamin B1 and fluoric sodium, vitamins D2 and glycyrrhizinate calcium (39,8 ± 2,42% and 30.2 ± 2,34% carious teeth, 4,88 ± 0.28 and a 3.87 + 0,40 carious lesions on the average on one of the rats, respectively). In this case we can say that the combination of drugs in both versions have not led to greater effect. Indeed, the addition of one glycerol calcium reduces negative influence on teeth to 3.50 ± 0,28 a rat on average, and one of fluoric sodium - to 4.68 + 0,33 a rat on average, i.e., the efficiency was about the same.
The combination of vitamin b, and glycerol calcium group (50) has considerably strengthened anticariogenic effect of each of drugs, as well as the combination of sea Kale with glycerol calcium (group 11). However, the greatest effect was achieved with simultaneous introduction of vitamin B6 and glycerol calcium. In the latter case it is possible to speak about strengthening the preventive effect in 2-2,5 times. If the animal group 23 this is caused by a combination of drugs and synergy of their action, in rats 12-th group, apparently, caused by the regular local effect on the teeth. In any case the results of our research show that the combination of sodium fluoride and glycerol calcium used endogenous and locally, gives the best effect is significantly larger than the single use of these drugs.
It should be noted that changed the course of the caries process, its localization in the mouth of animals. Significantly, in comparison with control, decreased frequency of lesions of the upper teeth. Initial caries was overwhelming majority in number of identified carious porajenii three groups (11, 18, 25), the number of medium and deep carious lesions varied 22,2 - 32,3%, the rest - just 6.4 - 9.6 per cent. Animals of the control group showed 34,6 + 2,5% heavy carious lesions.
Thus, the results of the research series of the animals who were given a simple combination drugs (no more than two), to be applied in some cases, in addition to endogenous introduction topically in the form of pastes, showed that the use of prevention tools in most of the experiments were more efficient and effective.
The best results of the prevention of dental caries was achieved first of all successful combination of drugs, joint additive effect of which was greatly enhanced anticariogenic effect (for example, glycyrrhizinate calcium and vitamin B1, glycyrrhizinate calcium and vitamin B6). In addition, the obvious synergies in General anticariogenic drug action was successfully supplemented by systematic local impact by applying various preventive pastes (laminaria and glycyrrhizinate calcium, sodium fluoride glycyrrhizinate and calcium). It should be noted that in proportion to the reduction in the incidence of dental caries has changed, or normalized, major subjects us indices mixed saliva and serum of blood. This once again testifies to the effectiveness and physiology of the drugs.

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