Tetracyclines

Tetracycline is a group of medicines active substance which is the antibiotic tetracycline, producyruemy Streptomyces aurefaciens and other related organisms.
1. Tetracycline (Tetracyclinum; synonymous with dechlorination; list B) is an antibiotic, effective against gram-positive and gram-negative bacteria, Rickettsia, and some viruses. Applied for the treatment of pneumonia, acute septic endocarditis, bacterial and amebic dysentery, whooping cough, gonorrhea, brucellosis, tularemia, typhus, typhoid, fever, urinary tract infections, chronic cholecystitis, purulent meningitis, peritonitis, surgical sepsisand burns, phlegmon, mastitis, blepharitis, keratitis, corneal ulcers and other diseases caused by sensitive microorganisms. Take inside for half an hour before or 1 hour after a meal in tablets or capsules of 0.1 - 0.2 g 4-6 times a day. The course of treatment 7-8 days. The highest daily dose of 2 g For parenteral injection (intramuscular injection and oral) use of tetracycline hydrochloride (Tetracyclini hydrochloridum). The solution are ex tempore of 1-2% solution novokaina (2.5-5 ml) at the rate of 0.05-0.1 g tetracycline on an injection. Enter tetracycline hydrochloride 2 - 3 times a day within 5-7 days. Single dose for introduction into the cavity 0,025-0,1 g Locally appointed in the form of suspension. Tetracycline may cause nausea, vomiting, loss of appetite, diarrhea, allergic reactions, the development of candidiasis. To prevent adverse effects caused by tetracycline, it is recommended to use it with vitamins. For this purpose let out the special tablet ("Wetzikon"). With the aim of preventing the development of candidiasis prescribed pills, containing tetracycline with nystatin. Tetracycline contraindications : hypersensitivity to him, fungal diseases, degenerative diseases of the liver, leukopenia, sharp violation of the kidney. Method of production: powder, pill 0.1 and 0.2 g (100 000-200 000 IU), capsules for 0.1 and 0.2 g (100 000 and 200 000 IU), suspension, ointment.
2. Oxytetracycline (Oxytetracyclinum; synonymous with terramycin). Indications for use are the same as for tetracycline. Assign into tablets or suspension of 0.1 - 0.2 g (100 000-200 000 IU) per reception 3-4 times a day. The course of treatment for 4 to 10 days. Higher doses: single 0.5 g (500 000 IU)daily, 2 g (2 000 000 UNITS). For intramuscular use solution oxytetracycline hydrochloride 1-2% solution novokaina. For the treatment of eye diseases (conjunctivitis, blepharitis, keratitis, trachoma and other) apply ointment. Contraindications are the same as for tetracycline.
Method of production: powder, pill 0.1 and 0.2 g (100 000 and 200 000 IU); eye ointment; suspension.
Cm. also Antibiotics, Chlortetracycline.