Accessories for titration: 1 - eyedropper; 2 - burette. |

Titration (titrimetry) is a method of quantitative analysis, based on the measurement of the volume of the solution of the reagent with the known exact concentration, reacted with a certain volume of solution of the analyte. It is measured by the eyedropper (Fig., 1) the volume of the analyzed solution, located in a conical flask, gradually add from burette (Fig., 2) m (i.e., known concentration) solution of the reagent. The titration is complete when the analyzed substance fully reacts with added reagent. The end of titration set by a colour change of the respective indicator (see), or in other ways. On a scale burette determine the amount of reagent solution, gone on titration. Normal concentration C1 and titer T solution of analyte (see Concentration) is calculated by the formula:

where * _{2} and_{2} - normal volume and concentration of the solution of the reagent, respectively, and e - equivalent to the weight (see) of analyte. This titration method called direct titration. Sometimes you need to apply back titration. In this case, the volume v1 analyzed solution adds redundant precisely measured amount corresponding reagent solution (reagent I). Unreacted excess of the reagent titrated solution of another reagent reagent II). Normal concentration C1 and titer T solution of analyte is calculated by the formula:

where * _{2}, *_{3} and_{2}, With_{3} - titrated volume of reagent solutions I and II and their normal concentrations, respectively.

On the application of titration in the laboratory and clinical practice - see Neutralization, method, Acidimetry, Deposition methods.