Syndrome de Toni-Debre - Fanconi's syndrome

It should be differentiated from the real syndrome in hypervitaminosis D, which in the enzyme deficiency tubular apparatus of kidneys develop severe metabolic disorders in a child's body. Centuries Siskova et al. (1971) on the basis of his own observations lead to the following differential diagnostic table of these diseases (table. 7) with some of our supplements.

Table 7. Differential diagnostic table of hypervitaminosis D syndrome de Toni-Debre - Fanconi's syndrome in infants
Indicators Gipervitaminoz D Syndrome de Toni-Debre-Fanconi's syndrome
Frequency Relatively often Rarely
Pathogenesis Violation of metabolism, mainly calcium, due to overdose of vitamin D Enzymopathy. Congenital tubulopathy. Impaired reabsorption of phosphorus, glucose and aminatta
The clinical picture Dry and pale skin, thirst, vomiting, constipation, hypotrophy, hypertension, liver enlargement Dry and pale skin, anorexia, thirst, vomiting, constipation, polyuria, malnutrition, liver enlargement. Hypertension is not. Hypotension muscles
Biochemical studies of blood Gipercalziemia in the acute period. Phosphorus reduced. Sugar and protein in norm. Alkaline phosphatase is not changed Calcium normal or reduced. Phosphorus is sharply reduced. Sugar and protein reduced sharply increased alkaline phosphatase activity. Metabolic acidosis
Urine The reaction of Sulkowice positive. Proteinuria, microhematuria, leukocyturia. Sugar aminosol more often in norm The reaction of Sulkowice negative. Proteinuria, phosphaturia, glycosuria, aminoaciduria
Radiography bones The expansion and consolidation zones prior to calcification Osteoporosis bone, areas of calcification poor in calcium