The treatment and prognosis of TB

In the past, until the middle of our century, TB treatment was carried out on the basis of rational hygienic and nutritional regime, according to the scheme: from peace through exercises to work. At that, special attention was paid to the rational calorie diet, rich in vitamins, due to the fact that chronic forms of tuberculosis was often accompanied by severe depletion.
In clinical practice since 1888 was introduced method of colapsoterapiei tuberculosis (see artificial Pneumothorax), which significantly increased the opportunity to help patients with pulmonary tuberculosis, especially with destructive forms.
Specific place in the treatment of pulmonary tuberculosis patients took surgical methods: thoracoplasty (see) and especially different types of lung resection, up to pneumonectomy (see).
In 1944, was opened streptomycin, thanks to which were first treated patients TB meningitis. A new era has dawned antibiotic and chemotherapy of tuberculosis. Were synthesized and other bacteriostatic drugs: sodium salt paraaminosalicilovaya acid (PAS) and (isonicotinic acid (especially tubazide). These three drugs are so-called 1 number of fully determined the prospects of clinical cure of tuberculosis. In some cases there is intolerance sick of these drugs; these may also be resistant Mycobacterium tuberculosis, resulting in treatment is unsuccessful. Further research on the synthesis of tuberculosis drugs has led to the creation of drugs so-called II series - ftivazide, cycloserine, ethionamide, pyrazinamide, protionamide and others, which is prescribed in case of no effect when using drugs I stimulants.
The correct application of chemotherapy using different combinations of drugs and their methods of administration (oral, intramuscular, intravenous, in the form of aerosols) allows to achieve clinical cure in more than 90% of the cases provided long-term treatment. In the absence of clinical cure, especially when residual destructive changes in light emitting mycobacteria, timely surgery followed by chemotherapy leads to clinical recovery.
Upon reaching the clinical cure, with the aim of preventing recurrence, patients subject to medical supervision with periodic chest x-ray.
Signs of clinical cure. General (objective) - resistant normal temperature, sustainable weight, absence of tachycardia, normalization of the blood formula and ROE. Local (pulmonary - sputum no or poor, BC in the sputum is not detected, no cough, catarrhal phenomena observed or possible only wheezing, radiologically - signs of healing.