Menadione (vitamin K)

Menadione (Vikasolum; list B) - protivogemorroidalnoe means; synthetic water-soluble analogue of vitamin K. Used in capillary bleeding, hepatitis, radiation sickness and other diseases involving hemorrhagic phenomena. Enter the inside 0,015-0,03 g or intramuscularly in a dose of 0,01-0,015 g / day 2-3 reception for 3-4 days; after a 4-day break course repeat. Forms: tablets : 0.015 g and 1% solution in sealed to 1 ml

The lack of vitamin To happen to blood clotting abnormalities and there is increased bleeding. "Collapse" Latin for "coagulation". On the first letter of this word vitamin K and got its name.
The main source of vitamin K are green parts of plants. A lot of it in the leaves alfalfa, chestnut, spinach, cabbage and cauliflower. The ability to form vitamin K also have bacteria living in the gut, in particular E. coli. Animal products contain almost no vitamin K. Very small amounts are present in milk and eggs. Vitamin K, extracted from plants, and vitamin K, synthesized by bacteria, differ from each other according to its chemical structure and the power of its effect on the human body. The first of them was named K1 second - K2.
Chemists managed to create a number of compounds that have the same effect on the body as natural vitamins K. One of these compounds called vitamin K3. Academician A. Century Palladin received a derivative of the vitamin - menadione, the big advantage of which is its solubility in water.
The daily requirement for vitamin K is uncertain. It is assumed that the adult she is much less than one milligram, and the newborn does not exceed 0.005 per milligram.
There are a number of diseases in which there is a slow the clotting of blood and, as a consequence, increased bleeding. Blood clotting is a very complex process. Violation of it may depend on a number of reasons, one of which is the lack of content in the blood of a special substance - protrombina, formed in the liver under the influence of the vitamin. K. to Develop prothrombin can only healthy liver, and the patient loses this ability.
Vitamin K is soluble only in fats. Because of diseases in which the absorption of fat is broken, can lead to K-vitamin deficiency. One of the most common causes of it are liver disease, in particular stones in the gall bladder. Formed when the disease stones often block the bile duct, causing jaundice, impede the flow of bile in the intestine and thereby violate the absorption of fat and vitamin K. Doctors have long been known propensity of patients with cholelithiasis during operations to heavy bleeding, which are dangerous for the life of such patients. Now the reason of such bleeding is known, and all suffering from liver disease before surgery enter the vitamin K.
The possibility of a K-vitamin take into account also in the appointment of certain medications (salicylic acid, sulfidina, antibiotics), which, suppressing the activity of intestinal bacteria simultaneously prevent and they develop vitamin K.
Of great significance was the discovery of vitamin K to prevent manifestations of K-vitamin deficiency in newborns, in the blood which often contain a small amount of prothrombin. In these cases, the compression of the head of the child during delivery may develop intracranial hemorrhage, damaging the tissue of the brain and often ends in the death of the child. Observations of physicians showed that in cases where mothers received prior to delivery vitamin K, blood clotting in newborns occurred within 30-60 seconds. In children, mothers were not introduced vitamin K, for coagulation often required to 6 minutes or more. Thus, the purpose of mothers in the last weeks of pregnancy vitamin K leads to a considerable increase in the number of prothrombin in the blood of newborns and protects them from danger intracranial hemorrhages and other manifestations of vitamin K.
It has been observed that vitamin C accelerates the clotting of blood not only for liver diseases, and other diseases, accompanied by reduced levels of prothrombin in the blood.
Preparations of vitamin K are available only by prescription. In high doses, especially in long-term use, vitamin K can have a toxic effect and lead to an excessive increase in blood clotting, which is especially unfavorable for the elderly.