Impact on the cervix with dysfunctional uterine bleeding

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Clinicians from ancient times it was known that in certain pathological conditions menstrual and fertility irritation of the cervix in the form of dilations cervical canal lead to favorable results. At first, this effect was explained by purely mechanical impact on bandwidth that, allegedly, had the desired therapeutic result. However, a number of experimental studies conducted in the thirties and fifties, has shown that the mechanism of irritation of the cervix of the impact on sexual cycle is more complex.
In experiment on rabbits Fee and Parkes (1929) found that the compulsory appearance of ovulation after mating can be prevented if the female is not later than one hour after mating remove the pituitary gland. This experiment was a direct link between the act of copulation and the impact on the ovary by the pituitary gland.
In 1935 M. KIESELSTEIN expanded this experiment and said that the effect ovulation after mating can occur when covering females vasectomypenis male, i.e. excluded humoral influence of ejaculate. In addition, M. KIESELSTEIN found that if the female to exterminate upper cervical sympathetic ganglia, ovulation after mating does not occur. Thus, it was found essential part in effect postoperational ovulation sympathetic nervous system.
A significant contribution to the study of this effect made Sawyer, Markee, Harris, Kawakami. The work of these researchers found that a similar effect can be obtained without mating, and only irritating vagina female rabbits glass rod. This has been fully proved that ovulation occurs not as a result copulating excitation, and only due to the irritation of the receptors of the vagina and cervix. In particular, a similar effect, but at the irritation of the cervix electric shock received M. KIESELSTEIN. The researchers noted that ovulation after the irritation of the cervix occurred more often than above was by this time estrogenic saturation: a preliminary introduction to the DOE-rabbit estrogen increased 4-5 times the frequency of ovulation during irritation of the vagina with a glass rod.
Research Werly, Sommerwille, Marrien (1963) found that females rabbits in the first days after the irritation of the vagina and cervix experiencing the allocation of pregnandiol.
Experiments with implantation of electrodes conducted Porter, Cavanaugh, Critchlow, Sawyer (1957), Sawyer, Kawakami (1959), De Feo, Reynolds (1960), Manaka, Kawakami (1971)found that the irritation of the cervix in rabbits conducted by mechanical or electrical means, leads to slow biopotentials in spontaneous bioelectric activity of the basal part of the forebrain, coming through 30 after causing irritation and continuing 5-7 min, i.e. during the period when the animal after mating occurs drowsy reaction in behavior. Also defined hypersynchronous of biopotentials in subcortical structures resembling that of saturation of organism with progesterone, and response inhibition of activity of the reticular formation. When implantation of electrodes in arcuate kernel, the median preoptions area of the hypothalamus and the hippocampus was found that electrical stimulation of the cervix rats causes characteristic changes of bioelectric activity of these units. At the same time similar changes could be obtained if you enter the animals prolactin (LTH).
Thus, on the basis of experimental data was found that stimulation of the receptors of the cervix and vagina has a rapid effect on subcortical structures, including the hypothalamus and the limbic system. This influence is manifested in the form of changes, characteristic for the selection and luteinizing luteotrophic pituitary hormones.
Integration of a number of experimental works allows to recreate the following path irritation of the cervix, which ultimately leads to ovulation: pulses from the upper third of the vagina and cervix mainly through sympathetic conduction paths of the autonomic nervous system reaches the upper cervical sympathetic ganglion, then through the brain stem is received by the hypothalamus and the limbic system, causing a heated neurosecretory the activity of the hypothalamic cells that emit RF-LH. Improving the allocation of releasing factor leads to the emission of large quantities of LH by adenogipofiza that, in turn, induce ovulation, the formation of yellow body and appropriate pregravidarnaya changes in the endometrium (Fig. 30). Such representation enables us to call this complex neuro-humoral reflex cervico-hypothalamic-pituitary.

the scheme cervico-hypothalamic-pituitary reflex
Fig. 30. The scheme cervico-hypothalamic-pituitary reflex.
1 - the cervix; 2 - upper cervical sympathetic ganglia; 3 - the hypothalamus; 4 - pituitary; 5 - ovary.