Xanthomatose is one of the types of General reticulata characterized by disturbance of lipoid metabolism with the deposition of lipids, mostly of cholesterolin the cells reticulohistiocytosis system. Santanyi cell - large cells of the type of macrophages containing in the cytoplasm many drops of lipids. Accumulation santonij cells lead to changes in the bones (especially skull), liver, spleen, lungs, and skin. The disease has a number of varieties. Forecast in most cases bad. For the treatment of xanthomatose used x-ray treatments, sometimes with success. Cm. also Retikulez.