The course and prognosis of gastric ulcer

Uncomplicated form of peptic ulcer disease in its flow is characterized by the alternation of exacerbations and remissions. This may be allocated course options: periodically recurrent, with clear cyclic course, with long periods of remission, often recurrent, with little pronounced cycles of relapse and short periods of remission; continuously recurrent, where the effect of therapy would never end, "bright" the gaps are almost absent.
There are and latent peptic ulcers, which are detected only at section table. Sometimes these forms manifest themselves in one or another complication.
The tendency to relapse is conditioned by the preservation of pathologically distorted regulatory mechanisms of activity of a stomach and duodenal ulcers (referring to the neuro-endocrine disorders), as well as resistance of morphological changes gastro-duodenal system. Such endogenous disorder create preconditions for possible complications of the disease under the influence of any of exogenous factors (stress, errors in diet, and other).
A certain influence on the course of peptic ulcer has age. Juvenile ulcers often occur on the background of neurasthenia, are haste current, severe diarrheal illness, a high level of gastric secretion (L. P. Ryabov, 1966; M. B. Kosura, 1966). In elderly and senile age are more common stomach ulcers, is a pronounced tendency to complications, education kallusnykh ulcers (R. A. Petrov, 1961; A. G. Ghukasyan, A. Y. Ivanova-Neznamova, 1965).
Women often occurs relatively "soft" disease, less common complications (C. X. Vasilenko and others, 1966).
Forecast quo ad vitam uncomplicated form of peptic ulcer favorable, but there is a risk of complications, bleeding, perforation, penetration, stenosis and transition in malignant course.
Forecast quo ad valitudinem remains little satisfactory, for not a single patient with peptic ulcer disease is not guaranteed from the beginning of the new exacerbation of the disease.
In elderly and senile age is relatively high mortality and the prognosis is less favorable. Equally unfavourable for juvenile ulcers. There is a point of view about reducing the frequency of relapses with age (Bockus, 1963). The more acute and longer duration of disease, the worse the prognosis. Forecast ulcers gastric body is considered more serious than ulcers duodenal ulcer. However, Krag (1966) has traced for several years, the fate of 347 patients with peptic ulcer and watched more often favorable course with a stomach ulcer. According to him, the high rates of gastric secretion in the first hospitalization prognostically not propitious.
Some significance somatic the background against which the proceeds from the basic disease.
At the same time, the majority of patients suffer from peptic ulcer disease throughout life, even in cases of successful and effective therapy separate exacerbations of the disease.