Pathological physiology of peptic ulcer disease

Ulcers disease, the main symptom of which is a stomach ulcer or duodenal ulcer, is not local, and common disease of the organism. When ulcers stomach violated all of its functions. There secretion of gastric juice (sometimes with high acidity and large digestive force) in needamangalam period. Appear pathological types of food secretion: more excitable, less inert, asthenic and brake. In the different stages of the disease are all forms of dyskinesia of the stomach: Hyper - and hypokinesis, Hyper - and gipotonus; severely disrupted the pyloric sphincter; along with spastic state are atony and akinesis muscles gatekeeper. Occurs reflux - throwing alkaline content of the duodenum into the stomach.
All this has a significant impact on the normal evacuation of food from the stomach into the intestine. There are two forms of the disorder: when one fast food leaves the stomach, while the other - its transition into the duodenum slowed down. When localization of ulcers in the duodenum occur the same infringements of secretory and motor-evacuation function of the stomach, but more often excitable type of secretion and motor skills, and several different qualitative composition of gastric juice (pH, concentration of protein fractions, digestive activity).
Ulcers are violated not only the function of stomach, but throughout the gastro-hepato-pancreato-duodenal system. Often secondary diseases: cholecystitis and cholangitis, biliary dyskinesia apparatus and duodenal ulcers, secretory disorders of the pancreas, liver and intestines. When ulcers have the disorder closereadchannel mechanism of management of activity of the gastrointestinal tract damage not only secretory and motor functions, but also vascular and trophic nerves. This simultaneous combination damage innervating apparatus is one of the main reasons leading to the development and chronic for ulcers.
A significant role in the pathogenesis of peptic ulcer disease has and the fact that pathologically changed the stomach or duodenum becomes the focus of pathological activity, which, on the one hand, supports a pathological condition of cortical mechanisms of regulation of secretion and motor function of the stomach, its blood supply and flow of trophic processes in cells, and on the other, raises a number of reflex changes in the activities of other internal organs such as the heart, kidneys, endocrine glands. In this way the main "vicious" circle between the centers of cortical-subcortical nerve formations and gastro-duodenal system that causes chronic ulcers. To this "vicious" circle connects and a number of others, in particular between think tanks and the system of glands of internal secretion, which takes an active part in the development of ulcers.
There are acute and chronic forms of peptic ulcer. The acute form is characterized by rapid appearance, rapid development and, if the plague be not the end of the perforation, the same quick involution. This form is often observed in organic (trauma, inflammation, tumor) injuries of Central and peripheral nervous system, traumatic and chemical damage the mucous membrane of the stomach and intestine. But she has little in common with gastric ulcer and duodenal ulcer with classic ulcer disease.
The chronic form of the ulcer is characterized by slow, gradual development and long persistence of the ulcer no tendency him to heal and is accompanied by sealing the edges of ulcers, perigastric or paraduodenal.
The largest number of models of chronic ulcers created in connection with justification vascular, traumatic, chemical, toxic, peptic, nutritional, endocrine, neurogenic, reflex and corticosterone theories of peptic ulcer. All models provides for the mandatory participation of peptic factor. That he plays the decisive role in the mechanism of formation of ulcers. But peptic a pathogenic factor acquires meaning only in the case when it acts on trophically modified wall of the stomach or intestine. Such a background is created in kortiko-visceral model of peptic ulcer. Here interact two factors; the General (neurosis) and local (digestive action of gastric juice). Neurosis caused by dogs on the way Th. P. Pavlova, leads to the complex neurohormonal changes in the body that violates the functioning not only of secretory and motor, but also vascular and trophic innervation of the stomach and duodenum. This causes loss of strength fabrics of these bodies to digest the action of digestive juices and the increased activity of peptic factor. The plague in these cases is formed almost in 100% of cases and by clinical, pathoanatomical, endoscopy, x-ray and histological paintings corresponds chronic stomach ulcer or duodenal ulcer person. When kortiko-visceral model ulcer disease are observed similar changes of the functions of the gastro-hepato-pancreato-duodenal system and other autonomic systems of the body. The development of ulcerative process runs in the background of profound changes of the higher nervous activity of the animal (according to the method of conditional reflexes). With the normalization of the last roboeda ulcer, restoring the normal function of the stomach and other internal organs.