Ukowska-Setunsky disease

Ukowska-Setunsky disease (synonym Gafsa disease) acute alimentary toxic disease manifested by the defeat of skeletal muscle, kidneys and nervous system. Ukowska-Setunsky disease occurs when eating lake fish, in the tissues which accumulate toxic substances that enter the water from the soil and some plants. In humans or animals these toxic substances cause degenerative changes in the ganglion cells of the crust brain and horns lateral spinal cord, striated muscle fibres and epithelium of convoluted tubules of the kidneys.
In the Soviet Union flash Ukowska-Setunsky disease registered in the area of lakes Jukovskogo (Leningrad region) and Sartlan (Western Siberia), in the Kharkiv region and other
The disease begins in a few hours, days after eating poisonous fish and is manifested by a sharp pain in the muscles, aggravated by movement or feeling, vomiting, increased sweating, subfebrile temperature and by oliguria. Urine becomes the color of meat slops, when you study it detect protein, cylinders, myoglobin and creatine. In 1-2% of the cases ended in death from asphyxia or uremia, in many cases, a few days later comes the recovery. Transferred disease immunity does not leave. Treatment. The patient should be hospitalized. In the hospital are hemodialysis (using artificial kidney), and exchange transfusion of blood (phlebotomy and krovezamenitel), intravenous isotonic solution of sodium chloride and 5% glucose.
Prescribe bed rest and drink plenty of water.
Prevention: in the flare of the disease suspected to Ukowska-Setunsky disease, prohibit the eating fish from the reservoir to determine its toxicity (sample on cats, very sensitive to this poison and dying for several days after ingestion of toxic products).

Ukowska-Setunsky disease (synonym: Gafsa disease, Gafsa-ukowska disease) acute disease (alimentary toxic), manifested by the defeat of skeletal muscles and kidneys (mortally syndrome) with simultaneous involvement of the nervous system.
Ukowska-Setunsky disease known as rare outbreaks among the population fishing villages lakes Jukovskogo (Leningrad region, 1934-1935) and Sartlan (Western Siberia, 1946-1948) for supply of fish in unusual mode of reservoirs. The disease (more than 1000 cases) was observed in the period 1924-1940, among the workers Hafslo Bay in East Prussia. Fish (pike, perch and others) becomes toxic properties due, presumably, toxic substances, washed out of the soil, algae or ergot, enter the water at the change in the level of water reservoirs, primarily in spring and summer. Simultaneously with sick people and animals, feeding on fish.
Thermostable toxic substance is found mainly in rich in fat tissues of fish and acts on the nervous system through the vascular and other receptors, as well as the loss of glycogen in skeletal muscle and accumulation of lactic acid and the release of myoglobin, which passes through the renal glomeruli, damages tubular epithelium. Develop in severe cases death uremia. Giperkaliemia leads to myocardial damage. Re eat fish cause new bouts of illness.
Most pathological changes found in the nervous system (swelling, vacuolization until necrosis ganglion cells crust, horns lateral spinal cord), in skeletal muscle (necrosis fiber type canceroscope, especially in the calf, lumbar, respiratory muscles) and kidney (accumulation of granular protein mass in a cavity capsules, dull swelling convoluted tubule epithelium, plenty of fine cylinders).
The disease begins suddenly during physical stress (through 10-70 hour. after eating fish) redchajshie pain in the muscles of the feet, hands, waist, chest, growing at the slightest movement (acute nutritional myositis). Because of the sharp pain of the respiratory muscles difficulty breathing; develop cyanosis, dry mouth, rash, vomiting. Consciousness remains. Deep sensitivity saved. Palpation muscle and nerve trunks painful. Temperature is normal or increased to 38 degrees. Urine little, it is red-brown or brown color, contains protein from 0,5 to 12%, and the granular and hyaline cylinders, erythrocytes, myoglobin, creatine.
Pain attack lasts from 3 hours to 4 days, then the pain gradually subside, restored normal color of urine, but proteinuria remains within 1-3 weeks. In 1-2% of cases, death occurs from uremia, less often in the first hours of the disease from asphyxia damage the respiratory muscles.
Treatment: bed rest, heat, vitamin therapy, glikokol (due to muscular lesions). Appropriate modern methods of treatment of acute hemolytic kidneys, including exchange transfusion, hemodialysis.
Prevention stems from the etiology of the disease. Toxicity fish can detect a biological control: after feeding toxic products in cats is paralysis and they die in the coming days.