Protective synthesis

Liver inactivates many flowing substances. This process can be done in different ways: by oxidation, destruction and connection with other substances. One of the main mechanisms of detoxification - the so-called protective synthesis, i.e. the transformation of toxic metabolic products in more complex non-toxic complexes, which are excreted from the body. By type of such synthesis is the forms hippuric acid by combining benzoic acid with glycocoll. In normal conditions are formed and excreted in the urine insignificant amount of hippuric acid (0,1-1,0 g / day), its quantity increases by eating fruit with peel containing benthological sodium.
The synthesis of hippuric acid is a physiological basis of the sample with the load benzalkonium sodium proposed by the Quick and modified A. Ya. by Pytel (1945). Clinical-anatomical mapping (L. A. Vinnik, 1956) showed the existence of parallelism between the degree of anatomical lesion of the liver cells and reduced synthesis of hippuric acid in the formulation of samples of Quick - Pytel.

Load benzalkonium sodium is given in the amount of 4 grams per os. The amount of hippuric acid excreted in the urine during the first 4 hours after the loading is OK to 80% and higher in relation to put benzoylacetone sodium. The definition is not only a total for 4 hours removing the hippuric acid, but defining it in each time portion allows you to more accurately assess the degree of disturbance antitoxic function of the liver. Normal curve excretion the hippuric acid has a rapid rise in the 1-St and 2-nd hour followed a sharp decline to the 4th hour. Slow increase excretion by the end of the 4-hour research indicates severe violation of antitoxic function of the liver. In addition, this type of curve total number derived the hippuric acid, as a rule, considerably reduced. The total number of the hippuric acid in cases of the most severe liver injury can be reduced to 35-20%. Defeat moderate give the decrease excretion to 60-65%.

The value of the sample with benzalkonium sodium in its physiology, usability, sufficient sensitivity. Toxicity benthological sodium small, but there are observations about some deterioration other functional parameters after load benzalkonium sodium (E. K. Geller and N. He Kabakhidze, 1957; A. A. Krylov, 1960), so if the most severe lesions in the liver from statement samples, apparently, should refrain.
Modification of the sample with intravenous benthological sodium (10 ml of 1.8% solution) addresses the impact of the conditions of absorption in the gut, but the access violation blood to the liver cells, as cirrhosis of the liver, slows the flow of drugs in the liver and gives lower indicators of the sample.